DNTT-mediated DNA Damage Response Drives Inotuzumab Ozogamicin Resistance in B-cell Acute Lymphoblastic Leukemia.

Inotuzumab Ozogamicin (InO) is an antibody-calicheamicin conjugate with striking efficacy in B-cell acute lymphoblastic leukemia (B-ALL). However, there is wide inter-patient variability in treatment response, and the genetic basis of this variation remains largely unknown. Using a genome-wide CRISPR screen, we discovered the loss of DNTT as a primary driver of InO resistance.

Inter- and Intrasublattice Spin Mixing Conductance of the Antiferromagnetic Spin Pumping Effect in α-Fe_{2}O_{3}/Pt.

The spin pumping effect in antiferromagnets, which ultimately converts THz waves into a spin current, is the key physical mechanism leading to an essential function which harnesses the THz technology and spintronics. Here, we report thorough experimental investigations of the spin current induced by the antiferromagnetic spin pumping effect in epitaxial α-Fe_{2}O_{3} thin films having two distinct dynamic modes and unambiguously show that both the inter- and intrasublattice spin mixing conductance are equally substantial. Our experimental insight is an important advance for understanding the physics of transduction between the spin current and the staggered magnetization dynamics at THz frequency.

Macrocytic anemia, kidney dysfunction, and mortality in general population: Japan specific health checkup study.

Anemia and chronic kidney disease (CKD), which worsen bidirectionally, are associated with mortality in older adults. This study aimed to examine the association between CKD and the type of anemia and its impact on mortality in the general population. Data from a nationwide database of 203,280 individuals who participated in the annual "Specific Health Check and Guidance in Japan" evaluation between 2008 and 2011 were used.

PtGd Alloy Nanoparticles from Organometallic Pt and Gd Complexes and Hollow Mesoporous Carbon Spheres: Enhanced Oxygen Reduction Reaction Activity and Durability.

PtGd alloy nanoparticles supported in hollow mesoporous carbon spheres (HMCS; ) were successfully prepared by the thermal reduction of organometallic Pt and Gd complexes without oxygen atoms supported in the pores of HMCS. The structures of PtGd alloy nanoparticles were fully characterized by TEM, HAADF-STEM-EDS, XRD, XAFS, and XPS, suggesting the formation of uniform PtGd alloy nanoparticles with an average particle size of 5.9 nm.

Octanoic Acid and Decanoic Acid Inhibit Tunicamycin-Induced ER Stress in Rat Aortic Smooth Muscle Cells.

ER stress is a crucial factor in the progression of vascular cell diseases. Notably, octanoic acid (OA; C8:0) and decanoic acid (DA; C10:0), prominent components of medium-chain fatty acids (MCFAs), may provide potential health benefits. However, their effects on vascular smooth muscle cells (VSMCs) remain unknown.