Reduced survival for rural patients with hepatocellular carcinoma within a tertiary hospital network: treatment equality is not enough.

Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality globally, with increasing incidence rates in Australia. As most treatments are performed in metropolitan centres, we hypothesised that rural patients may be adversely affected.

Aims: To investigate survival outcomes and treatment access between rural and metropolitan HCC patients within a single tertiary hospital network.

Recurrent alterations are associated with esophageal adenocarcinoma brain metastases.

Unlabelled: Brain metastases in esophageal adenocarcinoma (EAC) patients are associated with poor prognosis and remain understudied. We performed multi-omics analysis with whole-genome sequencing and single-cell spatial transcriptomics on the brain metastases and matched primary tumors. Our analysis identified as a recurrent oncogene in EAC brain metastases, with 9 out of 10 cases harboring amplifications.

Vertical transmission of hepatitis B virus in the WHO African region: a systematic review and meta-analysis.

Background: More new infections with hepatitis B virus (HBV) occur annually in the WHO African region than in the rest of the world combined. We did a systematic review and meta-analysis to estimate the prevalence of hepatitis B surface antigen (HBsAg) in pregnant women and vertical transmission events in the region.

Methods: In this systematic review and meta-analysis, we searched PubMed, Embase, Scopus, Africa Index Medicus, and Africa Journals Online for publications between Jan 1, 1992, and Jan 7, 2024, with no language restrictions.

K-Means Clustering of Hyperpolarised C-MRI Identifies Intratumoral Perfusion/Metabolism Mismatch in Renal Cell Carcinoma as the Best Predictor of the Highest Grade.

: Early and accurate grading of renal cell carcinoma (RCC) improves patient risk stratification and has implications for clinical management and mortality. However, current diagnostic approaches using imaging and renal mass biopsy have limited specificity and may lead to undergrading. : This study explored the use of hyperpolarised [1-C]pyruvate MRI (HP C-MRI) to identify the most aggressive areas within the tumour of patients with clear cell renal cell carcinoma (ccRCC) as a method to guide biopsy targeting and to reduce undergrading.

Bridging the Gap: Enhancing Prostate Cancer Survivorship and Advocacy Among Ethnically Diverse Black Men Through Community Town Halls.

We present findings from town hall meetings held with ethnically diverse Black prostate cancer (CaP) survivors in 2022 and 2023. Four town halls (total participants, N = 265) focused on diagnosis, treatment, psychosocial support, and overall survivorship. Moderated by a long-term CaP survivor, each session featured a panel that included medical providers (urologic oncologists and clinical psychologists), as well as CaP survivors of American, Caribbean, and African origin and their spouses.