Publications by authors named "T MAJOR"
The concept that fibroblasts are critical mediators of inflammation is an emerging paradigm. In rheumatoid arthritis (RA), they are the main producers of IL-6 as well as a host of other cytokines and chemokines. Their pathologic activation also directly causes cartilage and bone degradation.
View Article and Find Full Text PDFDue to the better survival of patients with tumorous diseases, it is increasingly important to predict the side effects of radiotherapy, for which the Radiation-Induced Lymphocyte Apoptosis (RILA) method is proving to be effective in multicentric studies. Prostate cancer is the leading cause of cancer-related deaths among men worldwide, which is usually treated with radiotherapy. We recruited 49 patients with localized prostate cancer and performed RILA measurements before radiotherapy.
View Article and Find Full Text PDFArticle Synopsis
- Smoking and alcohol are major risk factors for oropharyngeal tumors, but there's a rise in HPV-related cases in younger patients; radiotherapy plays a crucial role in treatment.
- A study of 95 patients treated with radio- or radio-chemotherapy showed that HPV positive tumors had better local control and survival rates compared to HPV negative tumors, with smoking adversely affecting outcomes.
- The results suggest that treatment involving chemotherapy and radiation enhances survival for HPV-negative tumors more effectively, whereas the benefits are less pronounced for HPV positive tumors, highlighting the negative impact of smoking on response to treatment.