Prenatal development of adenohypophyseal cell types, ovary, and uterus of dromedary camel.

The somatotrophic and thyrotrophic cells were originally developed in the adenohypophysis from undifferentiated chromophobic cells at the foetal age of 4-8 weeks. The follicle-stimulating hormone cells appeared at a foetal age of 24-28 weeks. Prolactin and luteinizing hormone cells were first seen at of foetal age levels of 32-36 and 40 weeks.

The set of growth factors stimulatory for a transformed rat cell of line NRK-49F depends on the identity of the transforming virus.

Re-cloned rat fibroblast line NRK-49F was transformed by human adenovirus type 5 which had been grown in human cells of the KB carcinoma line. Cell subclones were isolated from seven independent transformation events, and seven untransformed cell subclones were isolated in parallel from control cultures which had been inoculated with lysate of uninfected KB cells. The adenovirus-transformed cells differed from the control untransformed fibroblasts by being typically small and cuboidal, showing multilayered growth, producing colonies in soft-agar medium, and growing to higher saturation density.