Publications by authors named "T M Wilkie"
Background: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity and mortality in the United States. Frequent exacerbations result in higher use of emergency services and hospitalizations, leading to poor patient outcomes and high costs.
Objective: Demonstrate the feasibility of a multimodal, digitally enhanced remote monitoring, treatment, and tele-pulmonary rehabilitation intervention among patients with COPD.
Article Synopsis
- Chronic obstructive pulmonary disease (COPD) is a prevalent and serious condition, highlighting the need for effective care approaches like pulmonary rehabilitation and early intervention during symptom flare-ups.
- The Healthy at Home study aims to explore a new digital care model for COPD patients over a 6-month period, recruiting 100 participants for its pilot phase.
- Participants will use technology like smartwatches and apps to monitor their symptoms and health data, allowing researchers to gain insights into disease behavior and improve care responses.
Background: There are ongoing concerns regarding the impact of Canada's cannabis legalization and commercialization on vulnerable persons such as those with serious forms of mental illness, including persons with schizophrenia-spectrum disorders and users of forensic mental health services. The primary objective of this study was to investigate the potential harms and mental health-related impacts associated with cannabis legalization on a sample of forensic patients in Ontario (N = 187).
Methods: Using a pseudo-prospective design, we investigated the frequency of cannabis use over a four-year period encompassing two years preceding and two years following the legislative change.
Article Synopsis
- Prenatal alcohol exposure (PAE) leads to cognitive impairments and specific facial deformities by causing the death of cranial neural crest cells (CNCs) due to ribosome dysfunction and nucleolar stress.
- Research shows that PAE can significantly repress ribosomal protein expression, leading to nucleolar stress and activation of p53-MDM2 pathways that trigger apoptosis in CNCs.
- Experiments in avian and murine cells, as well as zebrafish models, indicate that combining low-dose alcohol with deficiencies in ribosome-related genes aggravates craniofacial malformations, highlighting the importance of ribosome biogenesis in the developmental effects of alcohol.
Diagnostic markers are desperately needed for the early detection of pancreatic ductal adenocarcinoma (PDA). We describe sets of markers expressed in temporal order in mouse models during pancreatitis, PDA initiation and progression. Cell type specificity and the differential expression of PDA markers were identified by screening single cell (sc) RNAseq from tumor samples of a mouse model for PDA (KIC) at early and late stages of PDA progression compared to that of a normal pancreas.
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