[PHENOTYPICAL CHARACTERISTICS AND GENETICAL DETERMINANTS OF PATHOGENICITY OF STAPHYLOCOCCUS AUREUS, ISOLATED FROM BACTERIAL CARRIERS, RESIDING ON THE TERRITORIES WITH VARIOUS LEVELS OF ANTHROPOGENIC POLLUTION OF AIR ENVIRONMENT].

Aim: Comparative phenotypical and genetical evaluation of pathogenic potential of Staphylococcus aureus strains, isolated from resident bacterial carriers, residing on the territories with anthropogenic pollution of air environment of varying intensity.

Materials And Methods: S. aureus, isolated 3 times from mucous membrane of the anterior of nose from 210 children, were the object of the study.

[Cycloferon biological activity characteristics].

Aim: Study the effect of cycloferon in experimental and clinical conditions on persistence properties of aurococci as well as features of their morpho-functional reaction by atomic force microscopy.

Materials And Methods: The study was carried out in 12 Staphylococcus aureus clones isolated from mucous membrane of nose anterior part of a resident carrier. The effect of cycloferon in vivo was evaluated in 26 resident staphylococci carriers under the control of anti-carnosine activity of staphylococci.

[Structural and functional characteristics of betulin derivatives].

The effect of betulin derivatives on persistence properties of microorganisms was studied in vitro. It was shown that the antipersistence action of the betulin derivatives depended on their structure and the microbial species. The experimental data on the structure - function relation could be useful in development and synthesis of new agents for therapy of chronic infections associated with persistence of bacterial pathogens in macroorganism.

[Synthesis, modifications, and antimicrobial activity of the methylpiperazinyl amides of triterpenic acids].

N-Methylpiperazinyl amides of betulinic, platanic, glycyrrhetic, oleanolic, ursolic, and moronic acids were synthesized and modified. Betulin and betulonic acid showed antimicrobial activity against Staphylococcus aureus at a concentration of 90 mg/ml, and betulin manifested a bacteriostatic effect against Klebsiella pneumoniae at a concentration of 60 mg/ml. Among the studied N-methylpiperazinyl amides, the highest activity against S.

[Biological characteristics of microorganisms for prognosis of trophic ulcers course].

Aim: To substantiate the possibility to use the biological characteristics of microorganism, in particular, factors of its persistence, for assessment of severity of trophic ulcers of lower extremities.

Materials And Methods: Clinical examinations and bacteriological tests of 48 patients aged from 37 to 80 years with trophic ulcer of lower limbs were performed. Antilysozyme, anticomplement, anticarnosine as well as hemolytic activity of isolated microorganisms were assessed.