[Frequency and the mutation spectrum of GJB2-related disorders of hearing in children from Dagestan as compared with the central European part of Russia].

The sequencing of the entire coding region and the donor site of the splicing of the GJB2 gene has shown that prelingual neurosensory nonsyndromic autosomal recessive deafness/poor hearing in Republic Dagestan is genetically more heterogeneous than in the central European part of Russia. Thus, the number of the revealed mutations in the GJB2 gene in Dagestan was only 28% of the total number of alleles in patients tested. The main mutations in the GJB2 gene in Dagestan were represented by three forms typical for West Asia: 35delG mutation (22% of all mutant alleles), deltaE120 mutation (22%), both in the coding region, and IVS 1+1 G > A (44%) in the donor site of splicing.

[Pathophysiological characteristics of various types of hemodynamics in acute bronchopulmonary diseases in infants and young children].

Polycardiography, biomicroscopy and angiography of the bulbar conjunctiva were used to examine 54 children aged 1 month to 3 years in the acute period of bronchopulmonary inflammation. Diverse hemodynamic alterations were revealed at different levels of circulation, representing a successive chain of pathogenetic reactions at the basis of which there lie the adaptive mechanisms. The status of the terminal hemodynamics was analyzed in different phasic syndromes of the left ventricular systole.