The influence of training load and schedule on youth athletes' sleep.

Sleep is important for youth athletes, supporting sport-related recovery and performance, as well as growth and development. Sleep may be influenced by training factors; therefore, this study aimed to characterise youth athletes' sleep, and examine associations between training load, schedule and frequency, and sleep. Twenty-six youth basketballers (age: 14.

Objective Suffering: What is it? What Could it be?

There is an ongoing debate in bioethics regarding the nature of suffering. This conversation revolves around the following question: What kind of thing, exactly, is suffering? Specifically, is suffering a subjective phenomenon-intrinsically linked to personhood, personal values, feelings, and lived experience-or an objective affair, amenable to impersonal criteria and existing as an independent feature of the natural world? Notably, the implications of this determination are politically and ethically significant. This essay attempts to bring clarity to the subjective versus objective debate in suffering scholarship by examining the history of the concept of "objectivity," and putting that history in conversation with physician Eric Cassell's famous theory of suffering.

The Impact of Sleep on Cognitive Function in Youth Athletes.

Objectives: This study sought to characterize the sleep of youth athletes and investigate relationships between sleep measures and cognitive function.

Method: Youth netball athletes ( = 19, age; 16.58 ± 1.

BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate.

Editing the +58 region of the BCL11A erythroid enhancer has shown promise in treating β-globin disorders. To address variations in fetal hemoglobin (HbF) response, we investigated editing both +58 and +55 enhancers. Rhesus macaques transplanted with edited hematopoietic stem/progenitor cells (HSPCs) following busulfan conditioning exhibited durable, high-level (∼90%) editing frequencies post transplantation with sustained HbF reactivation over 4 years, without hematological perturbations.

"Control Freaks": Evaluating Concerns of Ableism in the Perinatal Environment.

This essay explores the relationship between the modern era's impulse toward control and the practices of family planning and disability-selective abortion. Drawing from experiences as a pediatric palliative care physician working within a busy fetal care program, as well as the social theory of sociologist Hartmut Rosa, the author argues that there is an unresolved cultural and professional conflict within perinatal medicine between maximizing control of the future and maximizing a culture of anti-ableism.