Publications by authors named "T M Shnaĭder"
Article Synopsis
- BDNF (Brain-derived neurotrophic factor) is vital for nerve cell growth and survival, with forms that bind to different receptors affecting brain development, especially during the neonatal period.
- Disruptions in BDNF levels during this critical time can lead to long-term behavioral issues, including increased anxiety and depression in adolescents.
- The study found that elevated levels of mature BDNF contributed to these behaviors, while mutant BDNF led to opposite transcriptional changes, suggesting a significant link between BDNF variations and the development of neurobehavioral disorders.
Generation and analysis of mouse embryonic stem cells with knockout of the Mcph1 (microcephalin) gene.
Vavilovskii Zhurnal Genet Selektsii
September 2024
Article Synopsis
- Chromatin is organized in a specific three-dimensional structure within the nucleus, crucial for genome functions, with proteins like cohesin and condensins helping in this organization.
- The study reveals that knockout of the Mcph1 gene in mouse embryonic stem cells leads to chromosomal issues and deregulated gene expression, particularly affecting metabolism and olfactory receptors, but not cell cycle control.
- The findings suggest that Mcph1 plays a critical role in maintaining genome integrity and offer insights into the function of condensin II, potentially providing a model for future research on chromatin structure and gene expression.
Article Synopsis
- The rise of filovirus outbreaks in Africa has created an urgent need for effective antiviral treatments.
- Researchers synthesized and tested various derivatives of two compounds, (+)-fenchol and (-)-isopinocampheol, discovering that those with an N-alkylpiperazine cycle showed the strongest antiviral activity against specific viruses.
- The antiviral effects of these compounds likely come from their ability to bind to surface glycoproteins of the viruses and their lysosomotropic properties, indicating they could potentially be dual-action agents worth further investigation.
Topologically associated domains (TADs) restrict promoter-enhancer interactions, thereby maintaining the spatiotemporal pattern of gene activity. However, rearrangements of the TADs boundaries do not always lead to significant changes in the activity pattern. Here, we investigated the consequences of the TAD boundaries deletion on the expression of developmentally important genes encoding tyrosine kinase receptors: Kit, Kdr, Pdgfra.
View Article and Find Full Text PDFAssessing cell lines with inducible depletion of cohesin and condensins components through analysis of metaphase chromosome morphology.
Vavilovskii Zhurnal Genet Selektsii
April 2024
One of the most productive strategies for finding the functions of proteins is to study the consequences of loss of protein function. For this purpose, cells or organisms with a knockout of the gene encoding the protein of interest are obtained. However, many proteins perform important functions and cells or organisms could suddenly lose fitness when the function of a protein is lost.
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