Publications by authors named "T M Shet"
Article Synopsis
- Variations in access to drugs globally make it hard to assess the effectiveness of modern treatments for patients with relapsed and refractory mature T-cell and NK-cell lymphomas in a study of 925 patients.
- * The study found that relapsed lymphoma patients had better overall survival rates compared to refractory patients after second-line treatment, with several factors identified as predictors of survival.
- * A new prognostic index (PIRT) categorizes patients based on risk factors into low, intermediate, or high risk, impacting 3-year overall survival rates, and highlights the superior outcomes of novel therapies compared to traditional chemotherapy.
Gross Evaluation of Breast Carcinomas Post-Neoadjuvant Chemotherapy Without Radio-opaque Clip Insertion.
Arch Pathol Lab Med
September 2024
Context.—: Gross evaluation of post-neoadjuvant chemotherapy breast carcinoma is challenging when the primary tumor is not localized before therapy with a radio-opaque wire/clip, a situation common in resource-constrained settings.
Objective.
Utility of leukocyte-associated immunoglobulin-like receptor-1 (CD305) in flow cytometric detection of minimal bone marrow involvement by B-cell non-Hodgkin lymphoma.
Anu Singh Jagruti Patil Sitaram G Ghogale Nilesh Deshpande Karishma Girase Navami Shetye Tanuja Shet
Cytometry B Clin Cytom
September 2024
Article Synopsis
- Multicolor flow cytometry (MFC) is an important tool for detecting minimal bone marrow (BM) involvement in non-Hodgkin lymphomas (NHL) that are often missed by trephine biopsies or imaging.
- In a study of 1,084 BM samples from patients with B-NHL, MFC identified 172 samples that appeared morphologically negative but had detectable lymphoma cells, demonstrating the technique's effectiveness.
- CD305 emerged as a critical marker in flow cytometry for identifying minimal BM involvement, with many cases showing only low-level presence of lymphoma cells that conventional techniques could overlook.
Surgical resection stands as the preeminent therapeutic approach for both primary hepatocellular carcinoma and metastatic liver malignancies. Its efficacy is contingent upon the attainment of a comprehensive excision while ensuring a sufficient future liver remnant (FLR). However, post-hepatectomy liver failure (PHLF) remains a significant challenge, particularly in patients with preexisting liver disease.
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- The incidence of breast cancer in urban India is rising due to lifestyle changes and risk factors, with younger women often diagnosed at advanced stages.
- The lack of awareness and existing social taboos make it difficult for women to seek timely medical help, leading to significant financial burdens on families and challenges in accessing quality care.
- This article reviews breast cancer management from diagnosis to treatment, emphasizing the unique context of low-middle-income countries and discussing both early and advanced stages of the disease.