"Double Capture" - a technique to differentiate narrow complex Supraventricular Tachycardias.

Background: There are various diagnostic manoeuvres to distinguish between atrial tachycardia (AT), atrio-ventricular nodal re-entrant tachycardia (AVNRT) and orthodromic re-entrant tachycardia (ORT) when assessing a narrow complex supraventricular tachycardia (SVT) in the electrophysiology (EP) laboratory. These manoeuvres are commonly used in combination to come to a diagnosis due to the inability of a single test to be able to reliably differentiate between the arrhythmias.

Objective: To determine whether a single captured His-synchronous simultaneous extra-stimulus in the atrium and ventricle ("Double Capture") can reliably distinguish the mechanism of a narrow complex SVT.

Trained immunity causes myeloid cell hypercoagulability.

The pathogenic basis for increased thrombotic risk in individuals with inflammatory diseases is poorly understood. Myeloid cell "trained immunity" describes persistent innate immune cell memory arising from prior exposure to an inflammatory stimulus, leading to an enhanced immune response to subsequent unrelated stimuli. We identify enhanced myeloid cell prothrombotic activity as a maladaptive consequence of trained immunity.

When the wild things are: Defining mammalian diel activity and plasticity.

Circadian rhythms are a mechanism by which species adapt to environmental variability and fundamental to understanding species behavior. However, we lack data and a standardized framework to accurately assess and compare temporal activity for species during rapid ecological change. Through a global network representing 38 countries, we leveraged 8.

Rethinking memory impairments: Retrieval failure.

A canonical view in the neuroscience of learning and memory literature is that failures in memory expression reflect storage failures, and hence, amnesic manipulations following training or following memory reactivation can permanently erase memory traces. In this review, we analyze extant literatures from the learning and memory domains suggesting that most if not all of these memory deficits can be restored with the appropriate retrieval cues. We contend that all experience-dependent manipulations conducted immediately after training or following memory reactivation result in new learning, which interferes with the original learning and hence makes information highly dependent on retrieval cues for memory expression.

Multiomic Analysis of Calf Muscle in Peripheral Artery Disease and Chronic Kidney Disease.

Background: Chronic kidney disease (CKD) has emerged as a significant risk factor that accelerates atherosclerosis, decreases muscle function, and increases the risk of amputation or death in patients with peripheral artery disease (PAD). However, the modulators underlying this exacerbated pathobiology are ill-defined. Recent work has demonstrated that uremic toxins are associated with limb amputation in PAD and have pathological effects in both the limb muscle and vasculature.