Spatial Abilities and Performance in Anatomy for Occupational Therapy and Physical Therapy Doctoral Students.

Spatial ability is the capacity to comprehend three-dimensional structures and positional relationships and to mentally manipulate these structures and relationships to predict the outcome correctly. Spatial ability, which requires extensive knowledge of three-dimensional relationships, contributes to success in endeavors such as studying human anatomy, a foundational component of rehabilitation science curricula. This investigation explored relationships between anatomy course grades, learning preferences, and spatial abilities of graduate healthcare students from two fields of rehabilitation science.

Thickness of the Stifle Joint Articular Cartilage in Different Large Animal Models of Cartilage Repair and Regeneration.

Objective: Regulatory guidelines for preclinical cartilage repair studies suggest large animal models (e.g., sheep, goat, [mini]-pig, or horse) to obtain results representative for humans.

Isolated Intraocular Rosai-Dorfman Disease.

Background/aims: To report a case of Rosai-Dorfman disease (RDD) presenting as a solitary, choroidal mass, initially suspicious for uveal melanoma, in a 72-year-old woman.

Methods: Retrospective case report of a single patient.

Results: A 72-year-old woman presented with sudden vision loss in the right eye.

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease. We conducted a GWAS using 21,468 ER-negative cases and 100,594 controls combined with 18,908 BRCA1 mutation carriers (9,414 with breast cancer), all of European origin. We identified independent associations at P < 5 × 10 with ten variants at nine new loci.