[Influence of antitumor system rhenium-platinum on biochemical state of the liver].

Influence of the antitumour rhenium-platinum system on biochemical liver characteristics in the model of tumor growth (Guerin carcinoma) was studied and possible hepatoprotective activity of rhenium cluster compounds when introducing them in different forms was shown, that was confirmed by decreasing of diagnostic enzymes activity in blood (aminotransferase--AST 6 times and ALT 5.6 times, lactatedehydrogenase 4.9 times, gamma-glutamyltranspeptidase 3.

[Beta-lactamases of clinical isolates of Enterobacteriaceae family].

Among 62 clinical strains of enterobacteria, isolated from intestinal tract, representatives of genus Escherichia made--67.4%, Klebsiella--4.84%, Citrobacter--4.

[Glycolysis and pentose-phosphate pathway ratio in staphylococcus from the female genitalia in norm and dysbiosis].

Decrease in intensity of lactate accumulation and activity of glycolytic enzyme such as: phosphofructokinase, fructose-1,6-bisphosphate aldolase, pyruvate kinase found in staphylococcus of the second group isolated at vaginosis in comparison with staphylococcus of the third group isolated at vaginosis and concomitant additional infection pathology as well in comparison with staphylococcus of the first control group. Minimal inhibitory effect (MIA) and increase of enzyme activity of pentosephosphate ways such as: glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, transketolase testify to an intensification pentose-phosphate ways and decrease in activity of found the second groups staphylococcus isolated at vaginosis in comparison with of the in third group isolated at vaginosis and additional infection pathology as well as in comparison with the first control group staphylococcus isolated at normal state of UGT.

[Comparative studying of anaerobic bacteria located in woman's reproductive ways in normal condition and dysbiosis].

Bacteriological investigation of obligate anaerobic bacteria located in UGT of two groups of the observed women has shown: that the microbiocoenosis of UGT of women of the group 1 can be determined as normal. Identification of these anaerobic bacteria revealed the presence of representatives of the following species: Lactobacillus spp., Bifidobacterium spp.

[Effect of intravaginal administration of antibiotics of different groups on microbiocenosis of the urogenital tract in mice].

The changes of qualitative and quantitative composition of microflora of the urogenital tract have been investigated in mice at intravaginal introduction of antibiotics belonging to Fluorchinolons, Penicillinums and Tetracyclinums. It is established, that the load by antibiotics amoxicilline/clavulanic acid, doxycycline and ofloxacinum results in development of adysbiosis condition in urogenital tract, that is expressed in a significant decrease of quantity of Lactobacilli and increase of occurrence of the representatives of conditionally pathogenous flora (Staphylococcuses, Streptococcuses, representatives of family Enterobacteriaceae). An increase of the ratio between the quantity of anaerobes and aerobes is observed when introducing antibiotic preparations.