Urinoma: an unusual case of emesis in a brain-injured child.

The evaluation of acute emesis in a multiple-trauma paediatric patient with severe traumatic brain injury can present a difficult but not unusual problem in the rehabilitation unit. The differential diagnosis will be discussed in a paediatric case in which emesis was related to a urinoma, secondary to ureteropelvic disruption, compressing the duodenum. We present a case of a 6-year-old Caucasian girl with severe brain injury who developed emesis while in rehabilitation.

Antisera against three connexin43 fragments react with a 43-kD protein localised to gap junctions in myocardium and human myometrium.

Gap junctions are thought to play an essential role in the control of parturition. In this study we attempted to synthesise three short peptides which match the portion of the amino acid sequence of the connexin43, protein predicted from the nucleotide sequence of cDNA clone and to produce an anti-peptide antibody which would detect gap junction protein in human myometrium. Three peptides were synthesized: (1) RKEEKLNKKEEE, (2) EJKKFKYGJEEH and (3) KNRVKGRSDPYH.

The amino acids that constitute sequence gamma 268-282 of fibrinogen are not involved in fibrin monomer polymerization.

Congenitally abnormal fibrinogens with impaired fibrin monomer polymerization have been described to contain single amino-acid substitutions localized in certain positions of the gamma 275-330 peptide region. To evaluate the role of the amino-acid sequence in the vicinity of Arg275 in fibrin monomer polymerization, the peptide fragment corresponding to gamma 268-282 was synthesized and used to obtain peptide-specific antibodies. These antibodies, when purified immunochemically on the immobilized peptide, bound to the intact fibrinogen and fibrin monomers with the same binding affinity.

Allosteric interaction of components of the replitase complex is responsible for enzyme cross-inhibition.

The enzymes of DNA polymerization and DNA precursor synthesis are assembled in the replitase complex during the S phase of the cell cycle. Cross-inhibition is a phenomenon shown by enzymes of the replitase complex, in which inhibition of one enzyme of the complex leads to inhibition of a second, unrelated enzyme. This inhibition occurs only in vivo and only during S phase.

Effects of feeding pattern and dietary regimen on growth and adipose tissue cellularity in polygenic obese mice.

The effect of varying feed intake and feeding pattern during the early postweaning period on growth, body composition and adipose tissue cellularity was studied in polygenic obese and control normal mice. Male mice were assigned to the following dietary treatments at 4.5 wk of age: stock diet fed ad libitum(AL), four palatable foods cafeteria-fed(CF), stock diet fed every 2 h by automatic feeders adjusted for maximum intake(MI), fed same procedure as MI but restricted to produce 70% of the gain of mice fed ad libitum(RE), and stock diet fed one meal/d the same amount fed RE mice(PM).