[Modifying effect of low-molecular metabolities on the state of extracellular matrix of connective tissue of animals].

On the basis of complex approach to bone and haematopoetic tissue interaction the authors studied the influence of low weight metabolites on stromal fibroblasts and components of extacellular matrix of bone and skin (collagen and glycosaminoglycans). Specificity of different metabolites action on physico-chemical abilities of type I collagen, amino acid composition changes, surface charge, ratio of alpha- and beta-compounds, BrCN-fragments of alpha-1 component cross-links was shown. The dose dependence of formiate effect on processes of proteins glycosilation, cross-linking in bone and cartilage connective tissue and serum glycoproteins was established.

[Influence of formate on free amino acids contents in tissues and organs of rats in vitro and in vivo].

In experiments in vitro and in vivo influence of formiate on free amino acids contents of tissues and organs of rats has been studied. Results of experiments showed a possibility of amino acids formilation in all investigated tissues. This process could be enzymatic.

[Role of formic acid in transformation of acetic and succinic acids in animal tissues].

Acetic and succinate acids KoA acyl derivatives interacting with formate were displayed to produce alpha-ketoacids--pyruvate and alpha-ketoglutarate. These acids also interact with formate and make pyruvic and malate acids, while alpha-ketoglutarate, evidently, tricarboxy acids. Interaction of formate with acetic and succinate acids inspite of occurring out of the tricarbone cycle increases the latter metabolic functions.

[Cartilage collagen in health and in pathology].

The paper deals with the latest data on structure organization of collagen proteins--basic and minor components of the extracellular matrix of the animal cartilage tissue. Their genetic determination and tissue specificity, differences in the initial structure, sizes of spiral and globular domains, availability of --SH- and --S--S-bonds are emphasized. Data are presented which confirm that the change in the collagen state is one of the determining factors in pathogenesis of the cartilage tissue.

[Collagen from human joint cartilage in deforming arthritis].

Type II collagen of human cartilage has been comparatively studied in norm and at deforming arthrosis. Collagen preparations are characterized by aminoacid composition and electrophoretic mobility in polyacrylamide gel. It is supposed that at deforming arthrosis the degenerative-dystrophic processes in the articular cartilage of man are caused by appearance of procollagen.