[Clinical and experimental study of spirulina efficacy in chronic diffuse liver diseases].

The results of examination of 60 patients presenting with chronic diffuse disorders of the liver and seventy experimental animals with toxic affection of the liver, having been administered spirulina treatments, suggest clinical-and-laboratory effectiveness of this drug. The hepatoprotective properties of spirulina are referrable to its antiinflammatory, antioxidant, membrane-stabilizing, and immunocorrecting actions. In this way the employment of spirulina is believed to be pathogenetically validated in chronic diffuse liver conditions, permitting stabilizing the process and preventing the transformation of chronic hepatitis into hepatocirrhosis.

[Effectiveness of geriatric preparations containing natural metabolites in studies on animals of different age].

The new geriatric agent Rikavit which contains natural metabolites, is described. Experimental trials have shown that this drug causes prolongation of the average and maximal life-span and normalization of the age-related changes in metabolic indices in experimental animals. It has also been found to increase the resistance of an aging organism to the hazardous effects (hypoxia, physical and medicamentous loads) and its adaptive potentials.

[Cholagogic effect of trimethylglycine in normal animals of different ages and in experimental atherosclerosis].

Trimethylglycine at a dose of 1.5 g/kg was found to produce marked bile secretory effect in young and old rats. In rabbits with experimental atherosclerosis, trimethylglycine increased the content of biliary acids in the bile and normalized the indexes of lipid metabolism in the blood serum.

[Corrective effect of trimethylglycine on the nicotinamide coenzyme and adenine nucleotide content of the tissues in experimental atherosclerosis].

Experiments on adult rabbits with experimental atherosclerosis induced by cholesterol (0.25 g/kg for 90 days) showed that chronic administration of trimethylglycine (1.5 g/kg for 30 days) prevented a decrease of the liver and myocardium content of nicotinamide coenzymes and adenine nucleotides.