Publications by authors named "T M Ortiga-Carvalho"
Prenatal Exposure to Herbicide 2,4-Dichlorophenoxyacetic Acid (2,4D) Exacerbates Zika Virus Neurotoxicity In Vitro and In Vivo.
Environ Toxicol
September 2024
Article Synopsis
- - The Zika virus can cause Congenital ZIKV syndrome (CZS) during pregnancy, leading to malformations like microcephaly, with varying prevalence across Brazil, particularly in the Northeast and Central-West regions.
- - A study found that exposure to the agrochemical 2,4-dichlorophenoxyacetic acid (2,4D), commonly used in Brazil, worsens the neurotoxic effects of ZIKV in human cells and mice models, resulting in smaller brain size and increased cell death.
- - There is a notable correlation between the prevalence of CZS and the use of 2,4D in certain Brazilian regions, suggesting that this agrochemical may enhance the transmission of Z
Sex-specific effect of antenatal Zika virus infection on murine fetal growth, placental nutrient transporters, and nutrient sensor signaling pathways.
FASEB J
July 2024
Article Synopsis
- - Maternal Zika virus (ZIKV) infection during pregnancy leads to serious complications like intrauterine growth restriction and neurological issues in newborns, and this study focuses on how ZIKV affects nutrient transport in the placenta.
- - In experiments with mice, male fetuses showed impaired growth and different responses in placental markers compared to female fetuses; male placentae exhibited lower nutrient transporter activity while female placentae had altered glucose transport mechanisms.
- - The research highlights sex-dependent differences in how the placenta responds to ZIKV, suggesting that understanding these mechanisms could help develop treatments for the complications associated with congenital Zika syndrome.
Objective: To investigate the potential impact of vitamin D (VD) serum levels on couples going through in vitro fertilization treatment in terms of embryo quality and pregnancy rates.
Design: A retrospective cohort study.
Setting: A private human reproduction center.
Objective: Vitamin D (VD) is a fat-soluble steroid hormone, synthesized by the skin, most known for its role in bone mineral balance. Vitamin D receptors (VDR) are also found in the female reproductive system, but their role remains unclear. The objective of this study was to analyze the relationship between serum vitamin D levels and the number of oocytes retrieved after ovarian stimulation.
View Article and Find Full Text PDFHashimoto thyroiditis is an autoimmune disease characterized by hypothyroidism and a high level of anti-thyroid autoantibodies. It has shown to negatively impact female fertility; however, the mechanisms are unclear. Ovarian follicular fluid appears to be the key to understanding how Hashimoto thyroiditis affecst fertility.
View Article and Find Full Text PDF