Publications by authors named "T M Nikitina"
Spatial organization of chromatin is essential for cellular functioning. However, the precise mechanisms governing sequence-dependent positioning of nucleosomes on DNA still remain unknown in detail. Existing algorithms, taking into account the sequence-dependent deformability of DNA and its interactions with the histone globular domains, predict rotational setting of only 65% of human nucleosomes mapped in vivo.
View Article and Find Full Text PDF[This corrects the article DOI: 10.1016/j.ekir.
View Article and Find Full Text PDFArticle Synopsis
- The rise of filovirus outbreaks in Africa has created an urgent need for effective antiviral treatments.
- Researchers synthesized and tested various derivatives of two compounds, (+)-fenchol and (-)-isopinocampheol, discovering that those with an N-alkylpiperazine cycle showed the strongest antiviral activity against specific viruses.
- The antiviral effects of these compounds likely come from their ability to bind to surface glycoproteins of the viruses and their lysosomotropic properties, indicating they could potentially be dual-action agents worth further investigation.
Identification of the Optimal Cultivation Period Required to Isolate Representatives of Mycobacterium abscessus Complex Isolated from Patients with Cystic Fibrosis.
Int J Mycobacteriol
January 2024
Background: In patients with cystic fibrosis (CF), representatives of the fast-growing Mycobacterium abscessus complex (MABSc) are often distinguished, but the culture of the material taken from such patients increases the growth time. We analyzed the terms of cultivation of MABSc representatives on dense nutrient media and also evaluated the productivity of a modified nutrient medium based on agar for the isolation of Burkholderia cepacia complex (BCC).
Methods: Sixty-four strains of MABSc isolated from patients with CF and suspected tuberculosis were analyzed.
Aberrant methylation of placental development genes in chorionic villi of spontaneous abortions with trisomy 16.
Vavilovskii Zhurnal Genet Selektsii
April 2024
In humans, aneuploidy is incompatible with the birth of healthy children and mainly leads to the death of embryos in the early stages of development in the first trimester of pregnancy. Trisomy 16 is the most common aneuploidy among spontaneous abortions of the first trimester of pregnancy. However, the mechanisms leading to the death of embryos with trisomy 16 remain insufficiently investigated.
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