Publications by authors named "T M Nelson"
Fibrotic and Emphysematous Murine Lung Mechanics Under Negative-Pressure Ventilation.
Am J Physiol Lung Cell Mol Physiol
January 2025
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and the progressive nature heightens the calamity of the disease. Despite countless existing COPD studies, lung mechanics are often reported under positive-pressure ventilation (PPV) and implications and extrapolations made from these studies pose serious restrictions as recent works have divulged disparate elastic and energetic results between PPV and more physiological negative-pressure counterparts (NPV). This non-equivalence of PPV and NPV needs to be investigated under diseased states to augment our understanding of disease mechanics.
View Article and Find Full Text PDFDomestic Use of E-Cargo Bikes and Other E-Micromobility: Protocol for a Multi-Centre, Mixed Methods Study.
Int J Environ Res Public Health
December 2024
Physical inactivity is a leading risk factor for non-communicable diseases. Climate change is now regarded as the biggest threat to global public health. Electric micromobility (e-micromobility, including e-bikes, e-cargo bikes, and e-scooters) has the potential to simultaneously increase people's overall physical activity while decreasing greenhouse gas emissions where it substitutes for motorised transport.
View Article and Find Full Text PDFArticle Synopsis
- CheckMate 204 study found that the combination of nivolumab and ipilimumab resulted in high intracranial objective response rates (icORRs) for patients with melanoma brain metastases (MBMs), prompting a need for standardized response criteria.
- Different assessment criteria (like mRECIST and volumetric measurements) showed higher icORRs and stronger correlations with progression-free survival (icPFS) and overall survival (OS) compared to RANO-BM and RECIST.
- The analysis suggests that mRECIST and volumetric criteria are reliable scales for future MBM trials, and response can be effectively measured even in patients with small lesions (<10 mm).
Archived FFPE cardiac tissue specimens are valuable for molecular studies aimed at identifying biomarkers linked to mortality in cardiovascular disease. Establishing a reliable and reproducible RNA extraction method is critical for generating high-quality transcriptome sequences for molecular assays. Here, the efficiency of four RNA extraction methods: Qiagen AllPrep DNA/RNA method (Method QP); Qiagen AllPrep DNA/RNA method with protocol modification on the ethanol wash step after deparaffinization (Method QE); CELLDATA RNA extraction (Method BP) and CELLDATA RNA extraction with protocol modifications on the lysis step (Method BL) was compared on 23 matching FFPE cardiac tissue specimens (n = 92).
View Article and Find Full Text PDFPatterns of Failure After Definitive Trimodality Therapy for Muscle-Invasive Bladder Cancer.
Clin Genitourin Cancer
October 2024
Article Synopsis
- The study assesses real-world outcomes and failure patterns in patients with muscle-invasive bladder cancer (MIBC) who underwent trimodality therapy (TMT) between 2000 and 2018, utilizing data from the Veterans Affairs database.
- Results indicate that out of 347 patients treated with TMT, 44% had no recurrence, while 37% experienced metastatic recurrence (MR) and 34% had local recurrence (LR), highlighting significant rates of recurrence within the patient population.
- The findings suggest that TMT is generally effective in treating MIBC, but the high recurrence rates, particularly with lymph node positive disease and pre-treatment hydronephrosis, stress the importance of ongoing patient monitoring and the exploration of better treatment strategies