Toward a better approach for measuring visual-search slopes.

The slope of the function relating response times to the number of stimuli in a visual-search display is commonly considered a measure of search speed and is extensively used to test theories of visual cognition. Unfortunately, this important measure is confounded in multiple ways so that many classical findings in the literature must be called into question. As a way out of this predicament, we here develop a new technique to measure search speed (data collected in 2022 and 2023): Instead of manipulating the number of stimuli that need to be searched via a set-size manipulation, we achieve the intended purpose by placing the search target at different spatial positions with respect to an a-priori-known search order.

Reaction dynamics of the methoxy anion CHO with methyl iodide CHI.

Studying larger nucleophiles in bimolecular nucleophilic substitution (S2) reactions bridges the gap from simple model systems to those relevant to organic chemistry. Therefore, we investigated the reaction dynamics between the methoxy anion (CHO) and iodomethane (CHI) in our crossed-beam setup combined with velocity map imaging at the four collision energies 0.4, 0.

Imaging the Ion-Molecule Reaction Dynamics of O + CD.

While neutral reactions involved in methane oxidation have been intensively studied, much less information is known about the reaction dynamics of the oxygen radical anion with methane. Here, we study the scattering dynamics of this anion-molecule reaction using crossed-beam velocity map imaging with deuterated methane. Differential scattering cross sections for the deuterium abstraction channel have been determined at relative collision energies between 0.

Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria.

Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequency of administration and thereby potentially patient compliance. Here, we report on an Fc-engineered variant with three amino acid substitutions Q311R/M428E/N434W (REW), that enhances plasma half-life and mucosal distribution, as well as allows for needle-free delivery across respiratory epithelial barriers in human FcRn transgenic mice.