Publications by authors named "T M Metso"
Article Synopsis
- The study investigates how vascular risk factors like blood pressure, diabetes, and body mass index relate to the risk and recurrence of cervical artery dissections (CeADs), a major cause of stroke in young people.
- Using genetic analysis, it found that higher systolic and diastolic blood pressure significantly increases the risk of CeAD, while higher body mass index showed unclear effects.
- The research suggests that β-blockers could lower the risk of CeAD, which could help shape prevention strategies and clinical trials related to this condition.
Article Synopsis
- The study investigates genetic variants linked to early-onset ischemic stroke (EOS) in individuals aged 18-59, contrasting with previous research focused on late-onset stroke (LOS).
- Researchers conducted a meta-analysis involving 16,730 EOS cases and 599,237 controls to identify significant genetic associations and compared results between EOS and LOS.
- Findings include two genetic variants associated with blood subgroups that show a stronger connection to EOS than LOS, indicating that genetic factors promoting blood clotting are particularly influential in early-onset cases.
Objective: Dissection of the carotid artery (CaAD) may result in aneurysm formation. The present study was undertaken to evaluate the time of onset of post-dissection extracranial carotid artery aneurysms (ECAA) following CaAD, and to analyse independent risk factors for the development of these aneurysms.
Methods: From four European stroke centres, 360 patients with extracranial CaAD were included.
Background And Objectives: Migraine, stroke, and cervical artery dissection (CeAD) represent a triad of cerebrovascular disorders with pairwise comorbid relationships and vascular involvement. Larger samples and recent advances in methodology invite systematic exploration of their shared genetics.
Methods: Genetic analyses leveraged summary statistics from genome-wide association studies of the largest available samples of each disorder, including subtypes of stroke (ischemic stroke, large artery stroke, small vessel stroke, and cardioembolic stroke) and migraine (with aura and without aura).
Article Synopsis
- Cerebral venous thrombosis (CVT) is a rare type of stroke primarily affecting young people, and its genetic causes are not well understood.
- A genome-wide association study involved 882 CVT patients and 1,205 matched controls to identify genetic factors associated with CVT risk.
- Significant findings highlighted 37 SNPs linked to the 9q34.2 region, with blood groups A, B, or AB having a higher risk for CVT compared to blood group O, suggesting important genetic insights into the condition.