Exercise augmentation compared to usual care for post traumatic stress disorder: a randomised controlled trial (the REAP study: Randomised Exercise Augmentation for PTSD).

Background: The physical wellbeing of people with mental health conditions can often be overlooked in order to treat the primary mental health condition as a priority. Exercise however, can potentially improve both the primary psychiatric condition as well as physical measures that indicate risk of other conditions such as diabetes mellitus and cardiovascular disease. Evidence supports the role of exercise as an important component of treatment for depression and anxiety, yet no randomised controlled trials (RCT's) have been conducted to evaluate the use of exercise in the treatment of people with post traumatic stress disorder (PTSD).

Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers.

Aims: To assess the tolerability and pharmacokinetic profile of single and repeat doses of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers.

Methods: A total of 31 subjects participated in two placebo-controlled, rising-dose studies. The first study assessed the pharmacokinetics and tolerability of single doses of marimastat of 25, 50, 100, 200, 400 and 800 mg.

Rotatory intra-articular dislocation of the patella in two dogs.

Two young (8 and 13 week old) dogs were referred for evaluation of acute lameness. Physical examination, radiography, and surgical exploration of their stifles confirmed rotatory intra-articular dislocations of the patella. The dislocated patellas were stabilized with wire into their anatomically correct positions and allowed to heal.

Myotonia in a cocker spaniel.

A 16-week-old, male cocker spaniel suffering from pelvic-limb "bunny hopping" as well as rigidity, spasticity, and ataxia in all limbs was evaluated. The clinical features, electrophysiological abnormalities, and muscle histopathological and histochemical evaluations led to a diagnosis of congenital myotonia. Myotonia is a disorder of skeletal muscle characterized by delayed relaxation of the muscle fiber in response to voluntary, mechanical, or electrical stimulation.

Unilateral and bilateral stifle arthrodesis in eight dogs.

Nine stifle arthrodeses in eight dogs were reviewed retrospectively to evaluate use of the limb, each dog's comfort, complications, and factors that may have influenced the final outcome. Ability to use the limb after unilateral fusion was good (limb used at all times) in three dogs, fair (limb used at all gaits except a gallop) in three dogs, and poor (limb used only when running) in one dog. Factors that appeared to affect the outcome included angle at which the stifle was fused and lesions in the ipsilateral coxofemoral joint.