Prospective and retrospective analysis of whole slide images of sentinel and targeted lymph node frozen sections in breast cancer.

Different types of digital modalities are currently available for frozen section (FS) evaluation in surgical pathology practice. However, there are limited studies that demonstrate the potential of whole slide imaging (WSI) as a robust digital pathology option for FS FS diagnosis. In the current study, we compared the diagnostic accuracy achieved with WSI to that achieved with Light Microscopy (LM) for evaluating FSs of axillary sentinel lymph nodes (SLNs) and clipped lymph nodes (LNs) from breast cancer patients using two modalities.

The anesthesia human resources crisis in Canada.

Human resources are essential to the safe and effective functioning of any health care system. Pressure on the health care workforce is of active global concern. There appears to be an anesthesia service delivery crisis in Canada.

Hyperglycemia-triggered lipid peroxidation destabilizes STAT4 and impairs anti-viral Th1 responses in type 2 diabetes.

Patients with type 2 diabetes (T2D) are more susceptible to severe respiratory viral infections, but the underlying mechanisms remain elusive. Here, we show that patients with T2D and coronavirus disease 2019 (COVID-19) infections, and influenza-infected T2D mice, exhibit defective T helper 1 (Th1) responses, which are an essential component of anti-viral immunity. This defect stems from intrinsic metabolic perturbations in CD4 T cells driven by hyperglycemia.

Does robotic-assisted unicompartmental knee arthroplasty improve alignment and outcomes?

Unicompartmental knee arthroplasty (UKA) continues to increase in popularity as an excellent option for patients with single compartment disease. Robotic-assisted UKA has emerged as an optional tool with hopes for improvement in component placement, limb alignment, and patient outcomes. Furthermore, as patients continue to educate themselves, robotic assistance will become increasingly prevalent.

Reusable Generic Clinical Decision Support System Module for Immunization Recommendations in Resource-Constraint Settings.

Clinical decision support systems (CDSS) are routinely employed in clinical settings to improve quality of care, ensure patient safety, and deliver consistent medical care. However, rule-based CDSS, currently available, do not feature reusable rules. In this study, we present CDSS with reusable rules.