Publications by authors named "T M Kapoor"

Article Synopsis
  • Intercostal neuralgia is hard to treat and can significantly impact a person's quality of life, even with various therapy options.
  • The report details a case of a 56-year-old man who experienced significant improvement in his chronic pain after receiving a spinal cord stimulator implant due to rib fractures and prior surgeries.
  • This suggests that neuromodulation therapies, like spinal cord stimulation, may be effective for treating intercostal neuralgia in similar patients.
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Purpose: To understand diversity, inclusion, and capacity of genetic counselors (GCs) in Australasia (Australia and New Zealand).

Methods: Individuals with or working toward a GC qualification in Australasia were invited to complete an online survey, between November 2022 and March 2023. Quantitative data were analyzed using descriptive statistics, 1-sample proportion -tests, 2-sample -tests, and χ tests.

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The γ-tubulin ring complex (γ-TuRC) is an essential multiprotein assembly, in which γ-tubulin, GCP2-6, actin, MZT1 and MZT2 form an asymmetric cone-shaped structure that provides a template for microtubule nucleation. The γ-TuRC is recruited to microtubule organizing centers (MTOCs), such as centrosomes and pre-existing mitotic spindle microtubules, via the evolutionarily-conserved attachment factor NEDD1. NEDD1 contains an N-terminal WD40 domain that binds to microtubules, and a C-terminal domain that associates with the γ-TuRC.

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Article Synopsis
  • Errors in maintaining proteostasis, which involves controlled protein degradation and recycling, are associated with aging, cancer, and neurodegenerative diseases.
  • The study investigates how the mechanoenzyme VCP interacts with deubiquitinases (DUBs) to facilitate the recycling of proteins by profiling VCP interactions within living cells.
  • Using advanced imaging techniques, researchers reveal that the DUB VCPIP1 binds to specific sites on VCP, enhancing its activity and helping coordinate the removal of ubiquitin from proteins after their unfolding for recycling.
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Deposition of wildfire smoke on snow contributes to its darkening and accelerated snowmelt. Recent field studies have identified dark brown carbon (d-BrC) to contribute 50-75% of shortwave absorption in wildfire smoke. d-BrC is a distinct class of water-insoluble, light-absorbing organic carbon that co-exists in abundance with black carbon (BC) in snow across the world.

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