HVTN 123: A Phase 1, Randomized Trial Comparing Safety and Immunogenicity of CH505TF gp120 Produced by Stably and Transiently Transfected Cell Lines.

Utilizing transiently transfected cell lines could significantly reduce manufacturing timelines for protein subunit vaccines. This trial compared safety and immunogenicity of human immunodeficiency virus (HIV) envelope CH505TF gp120 vaccines produced by upstream stable and transient transfection (each admixed with GLA-SE adjuvant, a TL4 agonist). Both vaccines were safe and well tolerated.

Beauty and the brain - Investigating the neural and musical attributes of beauty during naturalistic music listening.

Beauty judgments are common in daily life, but rarely studied in cognitive neuroscience. Here, in three studies, we searched for the neural mechanisms of musical beauty using a naturalistic free-listening paradigm applied to behavioral and neuroimaging recordings and validated by experts' judgments. In Study 1, 30 adults continuously rated the perceived beauty of three musical pieces using a motion sensor.

Effects of tattoos on the aesthetic appreciation of human stimuli as influenced by expertise, tattoo status, and age reflecting internalized social norms.

Scientific interest in body modifications continues to grow, and tattoos have recently become a subject of empirical aesthetics. While conceptual structures of tattoo aesthetics have been studied, the question of how tattoos are aesthetically appreciated has not yet been studied. In this study, we examined how tattoos influence the aesthetic appreciation of human stimuli and uncovered differences in beauty perceived by individuals older and younger than 50, which we consider indicative of different internalized social norms, experts (tattoo artists) and nonexperts, and tattooed and nontattooed individuals.

Genome-Wide Association Study and transcriptome analysis reveals a complex gene network that regulates opsin gene expression and cell fate determination in R7 photoreceptor cells.

Background: An animal's ability to discriminate between differing wavelengths of light (i.e., color vision) is mediated, in part, by a subset of photoreceptor cells that express opsins with distinct absorption spectra.

Bad beauty: Aesthetic judgments are influenced by references to morally contentious content in photographs.

Affective responses can influence evaluative judgments, but how are subjective beauty ratings affected by references to morally contentious elements in aesthetic stimuli? In an online experiment (N = 460), we investigated the relationship between two types of descriptive texts (Neutral vs. Negative) and the beauty ratings of 25 photographs that depict sources of environmental pollution. For each photograph, the neutral descriptive text contained general information, whereas the negative descriptive text addressed the pollution source.