[Melanoma and cancer emergence in persons of 20-60 years against normal quantity of cambial cells in morphofunctional zones].

In age groups from 20 to 60 years cell proliferation and differentiation happen in the morphofunctional zone in the electric field excited by 12 pairs of mother and daughter cells, which have turned out at cambial cells division. Thus in daughter cells the Src SH2 domain necessary both for cytoskeleton formation and tyrosinase activization is activated. If the conditions for strengthening of tyrosinase activity are created in organism, despite the high maintenance of cambial cells, the portion of Src participating in the cytoskeleton building can decrease to critical level that will lead to development of a malignant tumor.

[Participation of morphofunctional zones in aging processes].

There are morphofunctional zones in organism tissues, where proliferation and differentiation processes occur. Daughter cells are differentiated in the electric field excited by 12 mother and daughter cell pairs, turned out at cambial cell division. With aging, the cambial cell number is reduced to 7, close to thresholds level (6 cells), at which the differentiation of daughter cells is absent.

[Characteristics of proliferation and differentiation of cambial and daughter cells in morphofunctional zones in the normal epithelium and cancer using age aspect].

Work of cambial cells of normal epithelium occurs in morphofunctional zone consisting of two subunits with 12 cells in each. 12 pairs of maternal and daughter cells which have turned out at their division, create the electric field making a differentiation of daughter cells. But it is necessary to relax the cortex of epidermal daughter cells by expression of the SH3 domain of Src-kinase in them with the help of dermal cells that leads to depression of RhoA activity in epidermal cells and the further activation of the SH2 domain of Src in them responsible for a differentiation.