Publications by authors named "T M Hemalatha"

Article Synopsis
  • - The study explores a new hydrogel made from natural silk fibroin and a customizable collagen-like protein, designed for better wound repair through rapid crosslinking using light and a photo-initiator.
  • - This engineered hydrogel, called PASCH, shows superior stability and biological properties compared to control hydrogels made solely from silk fibroin.
  • - It promotes better cell adhesion and growth in lab tests, leads to enhanced wound closure in endothelial cells, and supports cell repair through various cytokines and growth factors, highlighting its potential for tissue engineering.
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Collagen, a key component of extracellular matrix serves as a linchpin for maintaining structural integrity and functional resilience. Concerns over purity and immunogenicity of animal-derived collagens have spurred efforts to develop synthetic collagen-based biomaterials. Despite several collagen mimics, there remains limited exploration of non-immunogenic biomaterials with the capacity for effective self-assembly.

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Myocardial infarction (MI) occurs due to the obstruction of coronary arteries, a major crux that restricts blood flow and thereby oxygen to the distal part of the myocardium, leading to loss of cardiomyocytes and eventually, if left untreated, leads to heart failure. MI, a potent cardiovascular disorder, requires intense therapeutic interventions and thereby presents towering challenges. Despite the concerted efforts, the treatment strategies for MI are still demanding, which has paved the way for the genesis of biomaterial applications.

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The present investigation was focussed on regeneration, evaluation and screening of somaclones for yellow leaf disease (YLD) resistance using in vitro mutagenesis from a popular susceptible sugarcane variety Co86032 using four chemical mutagens at three levels of concentration (sodium azide (SA) at 0.5 mg L, 1.0 mg L, 1.

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