Publications by authors named "T M Grana"
Article Synopsis
- Nematodes of a specific genus are valuable for studying how sex is determined due to their three types of sexual morphs—males, females, and hermaphrodites—leading to unusual sex ratios.
- A new, undescribed species (n. sp.) has been introduced, featuring a draft nuclear genome that is roughly 60 Mb and contains more than 11,000 protein-coding genes.
- Environmental factors play a role in whether offspring develop as hermaphrodites or females, and researchers were able to identify potential X chromosome scaffolds using an ancestral chromosomal framework.
The mechanisms by which nerve growth factor (NGF) increases the level of low density lipoprotein receptor-related protein (LRP1) are not known. Administration of nitric oxide synthase (NOS) inhibitors modulates several of the neurotrophic actions of NGF, including TrkA signalling pathway activation, increases in gene expression and neurite outgrowth. The present study investigated whether NGF regulates the transcription of LRP1 as well as the role of NO and the individual TrkA signalling pathways in this action of NGF.
View Article and Find Full Text PDFBackground: In multicellular organisms, cell-cell junctions are involved in many aspects of tissue morphogenesis. α-catenin links the cadherin-catenin complex (CCC) to the actin cytoskeleton, stabilizing cadherin-dependent adhesions.
Results: To identify modulators of cadherin-based cell adhesion, we conducted a genome-wide RNAi screen in C.
Scientists routinely integrate information from various channels to explore topics under study. We designed a 4-wk undergraduate laboratory module that used a multifaceted approach to study a question in molecular genetics. Specifically, students investigated whether Caenorhabditis elegans can be a useful model system for studying genes associated with human disease.
View Article and Find Full Text PDF