Publications by authors named "T M Geiger"
Article Synopsis
- Macrocycles are seen as effective tools for targeting hard-to-reach proteins inside cells, but improving them from initial linear structures is still a work in progress.
- Researchers studied linker modification to enhance macrocycle properties, focusing on FKBP51 and producing over 140 versions with different linkers.
- They discovered that these modifications led to better affinity, stability, and solubility of the macrocycles compared to earlier models, and emphasized the importance of understanding the 3D shapes of these molecules in drug development.
Article Synopsis
- The study focuses on improving the understanding and identification of molecular glue substrates related to the E3 ligase receptor cereblon (CRBN), commonly used in clinical degraders.* -
- Researchers engineered human CRBN constructs for efficient production in E. coli, achieving a balance between high binding activity and production ease.* -
- The team developed an "Enamine focused IMiD library" for high-throughput screening, successfully identifying effective binders and laying the groundwork for future CRBN glue discoveries.*
Typhoidal Salmonella enterica serovars, such as Typhi and Paratyphi A, cause severe systemic infections, thereby posing a significant threat as human-adapted pathogens. This study focuses on cytolysin A (ClyA), a virulence factor essential for bacterial dissemination within the human body. We show that ClyA is exclusively expressed by intracellular S.
View Article and Find Full Text PDFT cell inhibitory mechanisms prevent autoimmune reactions, while cancer immunotherapy aims to remove these inhibitory signals. Chronic ultraviolet (UV) exposure attenuates autoimmunity through promotion of poorly understood immune-suppressive mechanisms. Here we show that mice with subcutaneous melanoma are not responsive to anti-PD1 immunotherapy following chronic UV irradiation, given prior to tumor injection, due to the suppression of T cell killing ability in skin-draining lymph nodes.
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