Publications by authors named "T M G Zahn"
Article Synopsis
- Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin condition that causes blisters and other complications, and this study tested the safety of losartan, a medication that may slow its progression.
- The study was a phase 1/2 trial involving children aged 2-16 with confirmed RDEB, focusing on identifying any serious side effects of losartan over a treatment period of 10 months.
- Primary safety concerns monitored included severe drops in blood pressure, allergic reactions, and changes in potassium levels, along with evaluating the drug's effectiveness through various clinical scores.
Zoonoses such as ZIKV and SARS-CoV-2 pose a severe risk to global health. There is urgent need for broad antiviral strategies based on host-targets filling gaps between pathogen emergence and availability of therapeutic or preventive strategies. Significant reduction of pathogen titers decreases spread of infections and thereby ensures health systems not being overloaded and public life to continue.
View Article and Find Full Text PDFBackground: Post-cardiac arrest syndrome (PCAS) is a frequent complication following successful cardiopulmonary resuscitation and correlates with poor outcome. PCAS is characterized by an excessive inflammatory response to whole-body ischemia and reperfusion. Cytokine adsorption was suggested as an adjunctive treatment option for the removal of cytokines from the patients' blood to restore the physiological equilibrium of pro- and anti-inflammatory activity and thus mitigate hemodynamic instability and end-organ complications.
View Article and Find Full Text PDF[ZApprO versus ZÄPrO: results of a first comparative study].
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
December 2023
Background: More than 60 years after the enactment of the first Licensing Regulations for Dentists (ZÄPrO), a new Licensing Regulations for Dentists, the ZApprO, was implemented in 2020. The aims of this study were to evaluate and compare the "Course in Technical Propaedeutics" (TPK) with the course "Dental Propaedeutics with a Focus on Dental Technology" (ZPDT), which are based on different legal foundations.
Methods: The following parameters were compared after completion of the courses: (1) theoretical and practical knowledge, (2) regular department-internal learner evaluation, and (3) special evaluation of learning conditions by the learners and (4) by the instructors.
Article Synopsis
- Serotonin deficiency due to lack of the serotonin transporter (SERT) is linked to metabolic changes and increased inflammation in mice, particularly when fed a high-fat diet.
- Research involved comparing SERT-deficient mice with wild-type mice over 19 weeks to assess body weight, insulin resistance, and inflammation levels in adipose tissue.
- Results indicated that SERT-deficient mice exhibited greater insulin resistance, liver issues, and higher levels of inflammatory markers in their adipose tissue compared to the wild-type, suggesting a connection between SERT deficiency and heightened inflammation in response to a high-fat diet.