Publications by authors named "T M Freeland"

Article Synopsis
  • - The SOX transcription factor family plays a key role in development, and researchers conducted a study using extensive genetic data to explore relationships between SOX protein variants and clinical conditions.
  • - They identified 27 amino acid changes within the HMG-box of SOX proteins linked to various clinical pathologies, including a novel mutation in SOX15 associated with muscle abnormalities and SOX8 linked to intellectual disabilities.
  • - The study also discovered numerous conserved variants in other regions of SOX genes, with associations to conditions like seizures, cardiovascular issues, and eyesight problems, enhancing understanding of genotype-to-phenotype connections in this important gene family.
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SARS-CoV-2 (COVID-19) has infected millions of people worldwide, with lethality in hundreds of thousands. The rapid publication of information, both regarding the clinical course and the viral biology, has yielded incredible knowledge of the virus. In this review, we address the insights gained for the SARS-CoV-2 proteome, which we have integrated into the Viral Integrated Structural Evolution Dynamic Database, a publicly available resource.

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Many individuals with traumatic brain injury (TBI) rely on augmentative and alternative communication (AAC) supports to meet functional communication needs. The use of images to display message content may be advantageous for this population, given deficits in literacy, visual processing, and cognition. Grid and visual scene displays are two options for presenting images within AAC systems.

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Purpose The study purpose was to compare the speed and accuracy with which people with traumatic brain injury (TBI) identified themes depicted in visual scene and grid displays. Additionally, we compared the verbal responses associated with the 2 display types to determine whether adults with TBI tended to produce more action or naming messages. Method Thirteen adults with and 13 without TBI viewed grid and visual scene displays matched for content and theme.

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Screening patients admitted with stroke symptoms for risk of aspiration is often the responsibility of registered nurses (RNs). Simulation technology has become a widely used evidence-based form of training for healthcare professionals. The purpose of this study was to determine if the use of medical simulation mannequins as a training component is feasible when training and evaluating nurses administering swallowing screenings to stroke patients.

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