Publications by authors named "T M Ferrara"
Article Synopsis
- This study investigates the risk of hyponatremia (low sodium levels) associated with various antidepressants, including SSRIs, SNRIs, and NRIs, through examination of health records in the All of Us Research Program.
- The overall incidence of hyponatremia was found to be 0.87% within the first 30 days and 10.5% over three years among participants taking these medications.
- Among the antidepressants studied, duloxetine and escitalopram had the highest risk for hyponatremia, while bupropion and paroxetine were linked to the lowest risk, helping providers make informed treatment decisions.
Article Synopsis
- Racial and ethnic differences in drug effectiveness and prescribing practices were evaluated for antihypertensive medications among Hispanic, Black, and White populations enrolled in the NIH All of Us Research Program.
- The study found that Black and Hispanic participants started on medications had higher initial systolic blood pressure and were prescribed fewer first-line treatments compared to White participants.
- Overall, antihypertensive drugs generally showed lower effectiveness in Black and Hispanic populations, indicating a need for earlier intervention and tailored treatment strategies for these groups.
Article Synopsis
- - The All of Us Research Program aims to enroll over a million participants to enhance precision medicine, focusing on the verification of biobanks by replicating known associations, specifically related to cigarette smoking.
- - The study used electronic health records (EHR) and participant surveys to assess smoking behavior and conducted a phenome-wide association study (PheWAS), comparing findings to published meta-analyses.
- - Results showed that a significant number of smoking-related phenotypes from meta-analyses were replicated in the All of Us data, demonstrating the program's potential for researching common exposures.
The carbazole compounds (1-(9-ethyl-7-(furan-2-yl)-9H-carbazol-3-yl)-N-methylmethanamine) and (1-(9-ethyl-7-(thiazol-4-yl)-9H-carbazol-3-yl)-N-methylmethanamine), second-generation analogues of (1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine), restore p53 signaling in Y220C p53-mutated cancer cells by binding to a mutation-induced surface crevice and acting as molecular chaperones. In the present paper, these three molecules have been tested for mutant p53-independent genotoxic and epigenomic effects on wild-type p53 MCF-7 breast adenocarcinoma cells, employing a combination of Western blot for phospho-γH2AX histone, Comet assay and methylation-sensitive arbitrarily primed PCR to analyze their intrinsic DNA damage-inducing and DNA methylation-changing abilities. We demonstrate that small modifications in the substitution patterns of carbazoles can have profound effects on their intrinsic genotoxic and epigenetic properties, with and being eligible candidates as "anticancer compounds" and "anticancer epi-compounds" and a "damage-corrective" compound on human breast adenocarcinoma cells.
View Article and Find Full Text PDFGliomas are complex and heterogeneous tumors that originate from the glial cells of the brain. The malignant cells undergo deep modifications of their metabolism, and acquire the capacity to invade the brain parenchyma and to induce epigenetic modifications in the other brain cell types. In spite of the efforts made to define the pathology at the molecular level, and to set novel approaches to reach the infiltrating cells, gliomas are still fatal.
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