[Prooxidant-antioxidant condition under increased convulsive activity].

During the clinical-biochemical research it was found that the trand's manner of epileptic disease in general is determined by the oxidative-antioxidant balance condition in the sick organism. The experimental research, made on rats, which were under bemegrid kindling confirmed the supposition that the pro-antioxidant brain balance disruption is one of the major factors in the increased convulsive activity development and probably plays the key role in the genesis and clinical revelation of epilepsy.

[The activity of free-radical lipid-peroxidative reactions in the acute and late periods of severe craniocerebral trauma].

Severe craniocerebral injury is shown to result in intensification of processes of lipid peroxidation (LPO), decline in activity of the antioxidant system, which facts lead to further damage to the injured brain caused by products of LPO processes. Activity of LPO processes is recordable as is decline in activity of the antioxidant system after the treatment administered and in 12 and 24 months following the injury sustained as well. The authors recommend that natural and synthetic antioxidants be included into a complex of measures designed to treat severe craniocerebral injury.

[Free-radical perodixative reactions in the acute period of craniocerebral trauma].

The condition is analyzed of the pro-oxidant-antioxidant balance in patients in the acute phase of craniocerebral injury. The higher the degree of craniocerebral injury, the more enhanced are lipid peroxidation processes, the more apparent is the decline in the function of the bodily antioxidant system. Changes in metabolic processes were at their greatest in patients beyond forty four years of age, especially in women with severe craniocerebral injury.

[Free-radical and neuroimmune processes in primary and repeated craniocerebral trauma (in an experiment)].

The impact of primary and repeated brain injury (BI) (moderate contusion of the brain) on changes of pro- and antioxidative processes in the brain and blood, as well as on the body's neuroimmune responses during 30 days following injury were studied in an experiment on albino rats. The changes in the rate of lipid peroxidation (LPO) were shown to be significantly higher in repeated BI than in primary one. There was no correlation between the changes in the rate of LPO in the blood and in the brain tissue.

[A clinical and experimental validation of the use of Stimuloss in patients with chronic generalized periodontitis].

The pharmacological effect of hydroxyapatite and a composition based on it in the form of Stimulos sponge has been studied in human osteogenic tissue culture. Hydroxyapatite stimulated the biosynthetic processes in the cells. Addition of chlorohexidine and thymogen to the composition in order to increase its antibacterial activity did not decrease the osteoinductive properties of the drug.