[Effect of exogenously administered ATP on heart function and energy status].

It has been shown that ATP (24.10(-6) M) administered once into the circulating solution improved strength and speed characteristics of aerobically perfused hearts. The increasing demands of the hearts in oxygen and energy substrates were satisfied due to coronary vessels dilatation without harming the energy status of the myocardium.

[Effect of ATP infusion on heart function in the post-perfusion period after aortocoronary bypass surgery in patients with chronic ischemic heart disease].

Using thermodilution technique, 110 patients have been examined during aortocoronary bypass surgery. Cardiac output, pump coefficient, cardiac index, stroke index, mean and edge pulmonary pressure, and other parameters of peripheral hemodynamics have been determined. At the end of the operation upon heart function recovery the test patients were administered intravenously a 1% ATP solution at a dose of 0.

[The role of fentanyl in protecting the myocardium from ischemic damage].

It has been shown that despite heart hypothermia to 12-15 degrees C the functional parameters under study following 60 min ischemia were considerably lower than their preischemic values. Introduction of fentanyl into the circulating solution enhanced noticeably the protective effect of hypothermia. At all the experimental stages the analgesic led to dose-dependent improvement of heart functions.

[Concentration of beta endorphin in blood as a criterion of adequacy of general anesthesia].

Considering beta-endorphin as a sign of tension and adaptation, the changes in its level have been studied during operations and surgery in patients with congenital heart valve defects subjected to cardiopulmonary bypass surgery. The goal of the study was determination of beta-endorphin concentration for the assessment of general anesthesia adequacy. A step-by-step study of beta-endorphin blood concentration, central and peripheral hemodynamics, diuresis, changes in temperature taken in 3 spots, adrenalin, dopamine and noradrenaline blood levels has been performed in 12 patients aged 4 to 17 years.