Publications by authors named "T M Coyne"
Introduction: Delineating subthalamic nucleus (STN) boundaries using microelectrode recordings (MER) and trajectory history is a valuable resource for neurosurgeons, aiding in the accurate and efficient positioning of deep brain stimulation (DBS) electrodes within the STN. Here, we aimed to assess the application of artificial intelligence, specifically Hidden Markov Models (HMM), in the context of STN localization.
Methods: A comprehensive search strategy was employed, encompassing electronic databases, including PubMed, EuroPMC, and MEDLINE.
Introduction: Infection after deep brain stimulation (DBS) implanted pulse generator (IPG) replacement is uncommon but when it occurs can cause significant clinical morbidity, often resulting in partial or complete DBS system removal. An antibiotic absorbable envelope developed for cardiac implantable electronic devices (IEDs), which releases minocycline and rifampicin for a minimum of 7 days, was shown in the WRAP-IT study to reduce cardiac IED infections for high-risk cardiac patients. We aimed to assess whether placing an IPG in the same antibiotic envelope at the time of IPG replacement reduced the IPG infection rate.
View Article and Find Full Text PDFCetaceans are well-regarded as sentinels for toxin exposure. Emerging studies suggest that cetaceans can also develop neuropathological changes associated with neurodegenerative disease. The occurrence of neuropathology makes cetaceans an ideal species for examining the impact of marine toxins on the brain across the lifespan.
View Article and Find Full Text PDFArticle Synopsis
- A 79-year-old woman with Alzheimer's participated in a Phase III trial for a drug called lecanemab, but was placed in the placebo group before later receiving the active drug during an extension phase.
- After her third infusion, she experienced a seizure and MRI scans showed significant brain swelling and increased microhemorrhages.
- Despite aggressive treatment, she worsened and died 5 days later, with autopsy results revealing severe cerebral amyloid-related inflammation and extensive brain damage linked to factors like the APOE4 gene.
The deep brain stimulation (DBS) Think Tank X was held on August 17-19, 2022 in Orlando FL. The session organizers and moderators were all women with the theme . Dr.
View Article and Find Full Text PDF