Publications by authors named "T M Compaore"
Association between extracellular matrix protein 1 (ECM1) gene polymorphisms (rs3834087 and rs3754217) and Hepatitis B Virus evolution in an African cohort.
Cell Mol Biol (Noisy-le-grand)
January 2025
Article Synopsis
- Hepatitis B virus (HBV) is a major global health concern linked to liver disease and cancer, with research focusing on genetic factors that affect its evolution.
- Recent studies highlighted the ECM1 gene, specifically two polymorphisms (rs3834087 and rs3754217), which may influence HBV pathogenesis, particularly in an African cohort analyzed in this research.
- The study found that the heterozygous genotype of rs3754217 appears to protect against chronic hepatitis, suggesting that certain genetic variations may impact the severity of the disease in infected individuals.
Purpose: The emergence of antibiotic resistance in pathogenic is a public health problem in tropical countries such as Burkina Faso. Antibiotic resistance could be identified using a variety of approaches. This study aimed to estimate the prevalence of pathogenic enterobacteria strains from three sources, as well as their antibiotic resistance profile to biotope and climatic season.
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- * The study involved 484 participants, primarily females, and found an overall dengue prevalence of 15.1%, with 2.9% of cases being asymptomatic. Subclinical and symptomatic cases made up 6.0% and 6.2%, respectively.
- * Determinants of dengue infection were analyzed, revealing that those who believed a virus transmitted dengue had significantly higher odds of being asymptomatic, indicating a connection between public perception and disease prevalence.
Noroviruses are the second leading cause of death in children under the age of 5 years old. They are responsible for 200 million cases of diarrhoea and 50,000 deaths in children through the word, mainly in low-income countries. The objective of this review was to assess how the prevalence and genetic diversity of noroviruses have been affected by the introduction of rotavirus vaccines in Africa.
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- Occult hepatitis B infection (OBI) is common worldwide, especially in regions like Africa, and can be spread through blood transfusions and organ transplants, with ties to liver cancer.
- A systematic review analyzed 83 studies to assess how common and genetically diverse OBI is across different African countries.
- Findings show OBI prevalence varies widely, peaking at 90.9% in hepatitis C patients and highlighting genotype D as the most prevalent strain in the continent.