Pinwheel-like Curved Aromatics from the Cyclotrimerization of Strained Alkyne Cycloparaphenylenes.

Carbon nanomaterials composed of curved aromatics, such as carbon nanotubes, are difficult to selectively synthesize and modify precisely. Smaller molecular fragments of curved nanomaterials, such as cycloparaphenylenes, benefit from the precision of bottom-up synthesis, however, efforts to expand the curved molecular framework into even larger structures often rely on restrictive early stage synthetic strategies or difficult to control polymerizations. In this work we report a high yielding, strain-promoted, late-stage modification of a series of [ + 1]CPPs.

A thermophysical investigation of weakly coordinated metals in ionic liquids.

Ionic liquids can solvate metals without strongly coordinating them, which gives a rare opportunity to probe the complexity of weakly coordinated metals through characterisation of liquid properties. In this work we use bis(trifluoromethanesulfonyl)imide ( bistriflimide; [NTf]) anions to prepare weakly coordinated metal containing ionic liquids (MILs) that are highly versatile because they are reactive with readily substituted ligands. Weakly coordinated metals are more than highly active catalysts.

Impact of Anatomical and Viability-Guided Completeness of Revascularization on Clinical Outcomes in Ischemic Cardiomyopathy.

Background: Complete revascularization of coronary artery disease has been linked to improved outcomes in patients with preserved left ventricular (LV) function.

Objectives: This study sought to identify the impact of complete revascularization in patients with severe LV dysfunction.

Methods: Patients enrolled in the REVIVED-BCIS2 (Revascularization for Ischemic Ventricular Dysfunction) trial were eligible if baseline/procedural angiograms and viability studies were available for analysis by independent core laboratories.

Effect of PCI on Health Status in Ischemic Left Ventricular Dysfunction: Insights From REVIVED-BCIS2.

Background: In the REVIVED-BCIS2 (Revascularization for Ischemic Ventricular Dysfunction) trial, percutaneous coronary intervention (PCI) did not reduce the incidence of death or hospitalization for heart failure (HHF).

Objectives: This prespecified secondary analysis investigated the effect of PCI on health status measured with the Kansas City Cardiomyopathy Questionnaire (KCCQ) combined with the primary outcome in a win ratio.

Methods: Participants with severe ischemic left ventricular dysfunction were randomized to either PCI in addition to optimal medical therapy (OMT) (PCI) or OMT alone (OMT).