Using machine learning to predict patients with polycystic ovary disease in Chinese women.

Objective: With an estimated global frequency ranging from5 % to 21 %, polycystic ovary syndrome (PCOS) is one of the most prevalent hormonal disorders. There are many factors found to be related to PCOS. However, most of these researches used traditional methods such as multiple logistic regression (LR).

Confinement of carbon dots into carboxymethyl cellulose matrice to prepare solid-state fluorescent films and couple with Eu-MOF toward white light-emitting diodes.

As a novel fluorescent carbon nanomaterial, carbon dots are restricted by their poor fluorescence in the solid state, although they exhibit favorable photoluminescence in solution. N-doped carbon dots (N-CDs) and solid-state fluorescence films were prepared using green and renewable cellulose-derived materials, respectively. The hydrogen bonding network of carboxymethyl cellulose (CMC) inhibits the self-aggregation behavior of N-CDs, which leads to solid-state fluorescence.

Efficacy and safety of first-line sintilimab plus anlotinib versus chemotherapy for metastatic non-small cell lung cancer: a phase II, open-label, randomized controlled trial.

Background: The prognosis for non-small cell lung cancer (NSCLC) patients treated with standard platinum-based chemotherapy was suboptimal, with safety concerns. Following encouraging results from a preliminary phase I study, this phase II trial investigated the efficacy and safety of first-line sintilimab and anlotinib in metastatic NSCLC.

Methods: In this open-label, randomized controlled trial (NCT04124731), metastatic NSCLC without epithelial growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), or proto-oncogene tyrosine-protein kinase ROS (ROS1) mutations, and previous treatments for metastatic disease were enrolled.

Heteronemin suppresses EGF‑induced proliferation through the PI3K/PD‑L1 signaling pathways in cholangiocarcinoma.

Epidermal growth factor (EGF) binds with its surface receptor to stimulate gene expression and cancer cell proliferation. EGF stimulates cancer cell growth via phosphoinositide 3‑kinase (PI3K) and programmed cell death ligand 1 (PD‑L1) pathways. As an integrin αvβ3 antagonist, heteronemin exhibits potent cytotoxic effects against cancer cells.

Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo.

INhibitor of Growth (ING1-5) proteins are epigenetic readers that target histone acetyltransferase (HAT) or histone deacetylase (HDAC) complexes to the H3K4Me3 mark of active transcription. ING5 targets Moz/Morf and HBO1 HAT complexes that alter acetylation of H3 and H4 core histones, affecting gene expression. Previous experiments in vitro indicated that ING5 functions to maintain stem cell character in normal and in cancer stem cells.