Publications by authors named "T M Bradford"
Visualization of guanine-rich oligonucleotides that fold into G-quadruplex (G4) helical structures is of great interest in cell biology. There is a large body of evidence that suggests that these noncanonical structures form and play important biological roles. A promising recent development highlighted fluorescence lifetime imaging microscopy (FLIM) as a robust technique for the direct and quantitative imaging of G4s in live cells.
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- The CAMP study is an ongoing research project aiming to assess the mid- and long-term effects of myocarditis and pericarditis following the Pfizer-BioNTech COVID-19 vaccine in patients under 21.
- It involves a cohort of at least 200 vaccinated patients and a comparison group of 100 patients with COVID-19 related myocarditis, collecting data over a 5-year span to track health outcomes and complications.
- As of October 16, 2024, the study has enrolled 273 participants, focusing on heart function, complications, and overall quality of life post-illness.
The early evolution of sex chromosomes has remained obscure for more than a century. The Vandiemenella viatica species group of morabine grasshoppers is highly suited for studying the early stages of sex chromosome divergence and degeneration of the Y chromosome. This stems from the fact that neo-XY sex chromosomes have independently evolved multiple times by X-autosome fusions with different autosomes.
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- Familial hyperkalemic hypertension (FHHt), also known as Gordon syndrome, results from abnormal WNK4 accumulation that activates the NaCl cotransporter (NCC) in the kidneys, primarily affecting the distal convoluted tubule (DCT).
- Mutations in the cullin 3 (CUL3) gene disrupt its interaction with the COP9 signalosome, leading to WNK4 accumulation and potential kidney injury, but short-term experiments show no significant plasma electrolyte changes in DCT-specific knockout mice.
- Long-term DCT-specific deletion of CUL3 causes kidney injury and atrophy, indicating that CUL3's role in degrading WNK4 is crucial for preventing FHHt, highlighting how the