Publications by authors named "T M Bock"
Article Synopsis
- HCN channels, particularly HCN1, play a crucial role in regulating neuronal excitability and are found in both pyramidal neurons and parvalbumin-positive interneurons in the hippocampus.
- This study used various advanced techniques to explore how HCN1 channels affect the release of GABA, an inhibitory neurotransmitter, from the axon terminals of these interneurons.
- Findings revealed that blocking HCN1 reduced GABA release, showcasing its importance in facilitating inhibitory signaling in the hippocampal CA1 region.
Stemness and pluripotency are mediated by transcriptional master regulators that promote self-renewal and repress cell differentiation, among which is the high-mobility group (HMG) box transcription factor SOX2. Dysregulated SOX2 expression, by contrast, leads to transcriptional aberrations relevant to oncogenic transformation, cancer progression, metastasis, therapy resistance, and relapse. Here, we report a post-transcriptional mechanism by which the cytosolic pool of SOX2 contributes to these events in an unsuspected manner.
View Article and Find Full Text PDFChimeric antigen receptor-modified T cell (CAR-T) immunotherapy has revolutionised blood cancer treatment. Parsing the genetic underpinnings of T cell quality and CAR-T efficacy is challenging. Transcriptomics inform CAR-T state, but the nature of dynamic transcription during activation hinders identification of transiently or minimally expressed genes, such as transcription factors, and over-emphasises effector and metabolism genes.
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- VPS4, an AAA-type ATPase, is recruited to viral assembly complexes in human cytomegalovirus infections to help with membrane constriction and fission, interacting with the viral protein pUL71.* -
- A specific peptide motif within pUL71 is crucial for this interaction, predicted to bind to VPS4A similarly to how cellular ESCRT-III components interact.* -
- This recruitment of VPS4A by pUL71 isn't essential for viral replication or morphogenesis, suggesting that its function remains unclear and highlighting a novel viral strategy that mimics cellular processes.*
The Epstein-Barr virus (EBV) is frequently found in endomyocardial biopsies (EMBs) from patients with heart failure, but the detection of EBV-specific DNA has not been associated with progressive hemodynamic deterioration. In this paper, we investigate the use of targeted next-generation sequencing (NGS) to detect EBV transcripts and their correlation with myocardial inflammation in EBV-positive patients with heart failure with reduced ejection fraction (HFrEF). Forty-four HFrEF patients with positive EBV DNA detection and varying degrees of myocardial inflammation were selected.
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