Publications by authors named "T M Baumann"
Article Synopsis
- Natural killer (NK) cells are vital for fighting metastasis, but disseminated tumor cells (DTCs) in the lungs release prostaglandin E2 (PGE), which leads to NK cell dysfunction.
- This dysfunction is triggered by PGE binding to specific receptors (EP2 and EP4), altering NK cell gene expression and reducing the production of important anti-metastatic signals.
- Targeting the PGE-EP2/EP4 pathway may provide a new therapeutic strategy to enhance NK cell activity against metastatic tumors in distant organs.
Article Synopsis
- - Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive type of skin cancer, often presenting as violaceous nodules or bruise-like plaques, with most cases showing significant skin involvement.
- - The cancer cells typically express specific markers (CD4, CD56, CD123, CD303) and common genetic mutations include TET2 and NRAS, identified through advanced genetic sequencing techniques.
- - Patients treated with aggressive chemotherapy followed by allogenic stem cell transplantation had better outcomes, especially younger patients or those receiving treatments similar to those for acute lymphoblastic leukemia (ALL).
Article Synopsis
- * A study involving 61 TLBCL patients analyzed their genetic characteristics compared to nodal DLBCL and primary CNS large B-cell lymphomas; findings indicated that TLBCL has fewer copy number changes but more somatic mutations than nodal DLBCL.
- * The results highlight a unique genetic profile for TLBCL, with most cases classified as MCD, indicating genetic diversity, suggesting that this lymphoma type warrants targeted treatment strategies due to its distinct biology.
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. Familial cases of PD are often caused by mutations of PTEN-induced kinase 1 (PINK1) and the ubiquitin ligase Parkin, both pivotal in maintaining mitochondrial quality control. CISD1, a homodimeric mitochondrial iron-sulfur-binding protein, is a major target of Parkin-mediated ubiquitination.
View Article and Find Full Text PDFThe performance of metal and polymer foams used in inertial confinement fusion (ICF), inertial fusion energy (IFE), and high-energy-density (HED) experiments is currently limited by our understanding of their nanostructure and its variation in bulk material. We utilized an X-ray-free electron laser (XFEL) together with lensless X-ray imaging techniques to probe the 3D morphology of copper foams at nanoscale resolution (28 nm). The observed morphology of the thin shells is more varied than expected from previous characterizations, with a large number of them distorted, merged, or open, and a targeted mass density 14% less than calculated.
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