Publications by authors named "T Lynch"
Importance: Active monitoring (AM) for low-risk ductal carcinoma in situ (DCIS) has been considered as a potential alternative to guideline-concordant care (GCC; inclusive of surgery with or without radiation). Reported data comparing patient-reported outcomes (PROs) between GCC and AM for DCIS are lacking.
Objective: To compare PROs at baseline and over time in patients with low-risk DCIS randomized to receive either AM or GCC.
Importance: Active monitoring for low-risk ductal carcinoma in situ (DCIS) of the breast has been proposed as an alternative to guideline-concordant care, but the safety of this approach is unknown.
Objective: To compare rates of invasive cancer in patients with low-risk DCIS receiving active monitoring vs guideline-concordant care.
Design, Setting, And Participants: Prospective, randomized noninferiority trial enrolling 995 women aged 40 years or older with a new diagnosis of hormone receptor-positive grade 1 or grade 2 DCIS without invasive cancer at 100 US Alliance Cancer Cooperative Group clinical trial sites from 2017 to 2023.
Article Synopsis
- Pediatric pneumonia diagnoses are tricky due to overlapping symptoms with other respiratory issues, subjective radiograph interpretations, and non-diagnostic lab results.
- The study analyzed children aged 3 months to 16 years in Canadian EDs before COVID-19, focusing on how accurately physicians could classify pneumonia types using an expert panel for consensus diagnosis.
- Findings showed a significant mismatch between physicians’ diagnoses and consensus results, with over-diagnosis of typical bacterial pneumonia and recommendations for specific clinical and lab indicators to better identify bacterial cases.
PPROM in the late preterm period: an argument for expectant management.
Am J Obstet Gynecol MFM
November 2024
Preterm prelabor rupture of membranes (PPROM) is associated with significant neonatal risks. When PPROM occurs during the late preterm period (between 34 0/7 and 36 6/7 weeks gestation), the optimal gestational age for delivery is unclear and varies by regional practice. In 2020 the American College of Obstetrician and Gynecologists (ACOG) published guidelines indicating that both expectant management and immediate delivery were considered reasonable options.
View Article and Find Full Text PDFArticle Synopsis
- Human parechoviruses (HPeVs) are significant causes of central nervous system infections in neonates, with a study conducted in Alberta from 2014 to 2019 focusing on HPeV-3 and the emerging HPeV-5 strains.
- Among the 18,882 cerebrospinal fluid samples tested, 56 were positive for HPeVs, with a higher prevalence in 2016 and a notable spike in infections during late summer to fall.
- The study found differences in mean ages of infection (18 days for HPeV-5 vs. 26 days for HPeV-3), and genetic sequencing suggested similarities with a recombinant strain identified in Australia, highlighting the need for ongoing research