Publications by authors named "T Loftus"
Indocyanine green fluorescent cholangiography in laparoscopic cholecystectomy: A systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.
Surgery
January 2025
Background: Indocyanine green fluorescent cholangiography is a noninvasive, real-time visualization method to prevent misinterpretation of biliary anatomy during laparoscopic cholecystectomy. This systematic review and meta-analysis focuses exclusively on randomized controlled trials that assess the efficacy of this technique during laparoscopic cholecystectomy.
Methods: MEDLINE, Embase, and Cochrane databases were searched up to August 2024.
Introduction: Despite continued improvement in post-sepsis survival, long term morbidity and mortality remain high. Chronic critical illness (CCI), defined as persistent inflammation and organ injury requiring prolonged intensive care, is a harbinger of poor long-term outcomes in sepsis survivors. Current dogma states that sepsis survivors are immunosuppressed, particularly in CCI.
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- The algorithmic patient preference predictor (PPP) aims to help make decisions for incapacitated patients when there are no advanced directives, highlighting both ethical challenges and practical issues in personalizing predictions.
- A review of studies found 68 using machine learning to predict patient-reported outcome measures (PROMs), with orthopedic and spinal surgeries being the most common focus; however, overall predictive performance was generally poor to moderate.
- Pre-event PROMs emerged as key predictors of post-event outcomes, indicating the need to integrate patient preferences into developing personalized PPP models, which currently lack adequate fairness assessments.