Association between antidepressant drugs and falls in older adults: A mediation analysis in the World Health Organization's pharmacovigilance database.

Objectives: The objective is to investigate the association between antidepressant drugs intake and falls reporting, as well as the potential mediators in-between, in older adults.

Methods: In VigiBase®, the World Health Organization's pharmacovigilance database, we performed a disproportionality analysis to probe the putative associations between each antidepressant drugs class (non-selective monoamine reuptake inhibitors [NSMRIs], selective serotonin reuptake inhibitors [SSRIs], serotonin-norepinephrine reuptake inhibitors [SNRIs], alpha-2-adrenergic receptor antagonists, and "other antidepressants") and reports of falls in people aged 65 and over (NCT05628467). The reporting odds ratios and their 95% confidence interval were derived from logistic regression models with adjustment for confounders.

Peritoneal Dialysis Patient Transfers to Hemodialysis: Causes and Associated Risks.

Background: The end of peritoneal dialysis (PD) can be marked by kidney transplantation, death, or transfer to hemodialysis (HD). We compared the risks of the different reasons for transfer to HD in PD patients according to the use of assistance for PD care, PD modality, and the suboptimal starter status.

Methods: This was a retrospective study using data from the French Language Peritoneal Dialysis Registry from patients who started PD between January 1, 2002, and December 31, 2018.

Early-Onset Peritonitis and Outcomes of Peritoneal Dialysis: A Cohort Study with Data from the RDPLF.

Introduction: Peritonitis occurring within the first months on peritoneal dialysis (PD) has been associated with poorer PD outcomes. Whether early peritonitis is a risk factor for transfer to haemodialysis in the long term is a matter of investigation.

Methods: This retrospective study was conducted using data from the French Language PD Registry of incident PD patients between 2002 and 2018.

A convergent mixed methods to study registration on kidney transplantation waiting list refusal by women and men on dialysis in France.

Not all patients on dialysis want to be registered on the kidney transplantation (KT) waiting list and undergo transplantation. The aim of this convergent mixed methods study was to determine the features of patients refusing to be registered on the KT waiting list and the reasons. Quantitative data on all 2017-2019 incident 18-85-year-old dialysis patients, eligible for KT, were extracted from the REIN registry in France.