Monte Carlo study of in-field and out-of-field dose distributions from a linear accelerator operating with and without a flattening-filter.

Purpose: To compare dosimetric characteristics of 6 MV photon fields originating from a linear accelerator operating with (FF) and without (FFF) a flattening-filter. The main objective is to establish a FFF model that results in similar depth-dose and build-up profiles as the original FF model, and subsequently estimate and compare out-of-field dose distributions.

Methods: The EGSnrc Monte Carlo user codes BEAMnrc and DOSXYZnrc are used for photon beam simulations of an Elekta linear accelerator and dose calculations in a water phantom, respectively.

Monte Carlo linear accelerator simulation of megavoltage photon beams: independent determination of initial beam parameters.

Purpose: To individually benchmark the incident electron parameters in a Monte Carlo model of an Elekta linear accelerator operating at 6 and 15 MV. The main objective is to establish a simplified but still precise benchmarking procedure that allows accurate dose calculations of advanced treatment techniques.

Methods: The EGSnrc Monte Carlo user codes BEAMnrc and DOSXYZnrc are used for photon beam simulations and dose calculations, respectively.

Superficial doses in breast cancer radiotherapy using conventional and IMRT techniques: a film-based phantom study.

Background And Purpose: Superficial doses in radiotherapy are affected by the treatment technique. The implications for breast cancer treatments were evaluated.

Material And Methods: Four treatment techniques relevant for breast cancer irradiation were evaluated; tangential standard, tangential IMRT, 7-field IMRT (arc-like field arrangement) and hybrid IMRT (an IMRT plan mixed with non-modulated fields).

Contralateral breast doses measured by film dosimetry: tangential techniques and an optimized IMRT technique.

The contralateral breast (CLB) doses for three tangential techniques were characterized by using a female thorax phantom and GafChromic EBT film. Dose calculations by the pencil beam and collapsed cone algorithms were included for comparison. The film dosimetry reveals a highly inhomogeneous dose distribution within the CLB, and skin doses due to the medial fields that are several times higher than the interior dose.

Second-harmonic generation in collagen as a potential cancer diagnostic parameter.

The fibrillar collagen network in tumor and normal tissues is different due to remodeling of the extracellular matrix during the malignant process. Collagen type I fibers have the crystalline and noncentrosymmetric properties required for generating the second-harmonic signal. The content and structure of collagen were studied by imaging the second-harmonic generation (SHG) signal in frozen sections from three tumor tissues, osteosarcoma, breast carcinoma, and melanoma, and were compared with corresponding normal tissues, bone/femur, breast, and dermis/skin.