Publications by authors named "T Leeb"
Article Synopsis
- * Affected dogs exhibited significant brain degeneration and the presence of harmful autofluorescent materials in their neurons, which contributed to a preliminary diagnosis of NCL.
- * Genetic analysis identified an 18,819 base pair duplication in the MFSD8 gene in both dogs, which is linked to NCL in humans and other mammals, confirming the diagnosis as NCL7 and enabling future genetic testing to prevent breeding carriers.
Canine exfoliative cutaneous lupus erythematosus (ECLE) is the rarest variant of cutaneous lupus in dogs and has strong breed predilections. This report presents the clinical, histopathological and immunohistochemical features of two ECLE cases in mixed breed littermates and confirms the expected genetic mutation. A therapeutic response to oclacitinib also is documented.
View Article and Find Full Text PDFMuscular dystrophies represent a group of disorders characterized by progressive muscle degeneration and weakness. An important subgroup are the dystrophin-related muscular dystrophies caused by variants in the DMD gene. They can be divided into the more severe Duchenne muscular dystrophy and the milder Becker muscular dystrophy.
View Article and Find Full Text PDFBackground: Neuroaxonal dystrophy (NAD) is a group of inherited neurodegenerative disorders characterized primarily by the presence of spheroids (swollen axons) throughout the central nervous system. In humans, NAD is heterogeneous, both clinically and genetically. NAD has also been described to naturally occur in large animal models, such as dogs.
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