Publications by authors named "T Lassalle"
Prospective, Observational, Multicenter, Real-World Study of the Efficacy, Safety, and Pattern of Use of the Dexamethasone Intravitreal Implant in Diabetic Macular Edema in France: Short-Term Outcomes of LOUVRE 3.
Laurent Kodjikian Cécile Delcourt Catherine Creuzot-Garcher Pascale Massin John Conrath Thibaut Lassalle
Ophthalmol Ther
June 2023
Introduction: To evaluate real-world efficacy, safety, and treatment patterns with the dexamethasone intravitreal implant (DEX) in diabetic macular edema (DME) in France.
Methods: In this prospective, multicenter, observational, noncomparative, post-reimbursement study, consecutively enrolled patients with DME had a baseline evaluation on day 0. Those treated with DEX on day 0 were to be reevaluated at week 6 and months 6, 12, 18, and 24.
Article Synopsis
- ERRα is a nuclear receptor that regulates metabolism and has been linked to cancer progression, particularly in tissues with high-energy needs, like those in breast, ovary, and colon cancers.
- Research using RNA interference revealed that silencing ERRα impairs colon cancer cell growth, colony formation, and tumor development, while also delaying critical cell cycle transitions.
- Further analysis showed that ERRα depletion disrupts energy metabolism by reducing key metabolic gene expression and glucose utilization, indicating that targeting ERRα could be a potential therapeutic strategy for colon cancer.