Publications by authors named "T Larsson"
Dwell time shaping in inverse treatment planning for cervical brachytherapy.
Phys Imaging Radiat Oncol
October 2024
Article Synopsis
- - The study aimed to improve cervical brachytherapy treatment planning by using a method called inverse treatment planning with pseudo-structures, hypothesizing it could achieve better dose distributions while meeting clinical standards.
- - Data from 16 previous patients was analyzed, comparing manual planning, straightforward inverse methods, and the pseudo-structures approach, with results indicating varying doses for the clinical tumor volume across the different methods.
- - The findings showed that using pseudo-structures effectively shaped the dwell time distribution and complied with clinical requirements, confirming its efficacy across two different planning systems.
Background: RMC-035 is a modified version of alpha-1-microglobulin, an endogenous protein developed as a renoprotective agent. Its intended use is to reduce the risk of irreversible loss of kidney function in cardiac surgery patients and to reduce delayed graft function in kidney transplant recipients. This first-in-human study aimed to evaluate the pharmacokinetics and safety of RMC-035 in kidney transplant recipients.
View Article and Find Full Text PDFBackground: Cardiac surgery invariably triggers acute kidney stress causing adverse renal outcomes. The AKITA study evaluated the efficacy and safety of RMC-035, a novel analogue of alpha-1-microglobulin, for reducing cardiac surgery-associated kidney injury.
Methods: In this randomised double-blind placebo-controlled phase 2a study, we randomly assigned (1:1) adult hospitalised patients undergoing open-chest cardiac surgery at high risk for acute kidney injury (AKI) at 21 sites in North America and Europe to receive either RMC-035 (1.
Species within nearly all extant animal lineages are capable of regenerating body parts. However, it remains unclear whether the gene expression programme controlling regeneration is evolutionarily conserved. Brittle stars are a species-rich class of echinoderms with outstanding regenerative abilities, but investigations into the genetic bases of regeneration in this group have been hindered by the limited genomic resources.
View Article and Find Full Text PDFArticle Synopsis
- The marine annelid serves as a valuable model organism in various research fields, including evolution, neurobiology, and regeneration.
- Researchers presented the genomes of this organism and its relatives, utilizing advanced sequencing technology to create a detailed draft genome assembly of approximately 1.47 billion base pairs.
- The study identified around 29,000 protein-coding genes, significant genetic variation, and emphasized gene functions related to pigmentation, development, and immunity, laying the groundwork for future genomic research.