The Effects of Nocturnal Hypoxemia on Cognitive Performance in Andean Highlanders.

Many Andean highlanders exposed to chronic hypoxemia are susceptible to excessive erythrocytosis (EE) and chronic mountain sickness (CMS). Nocturnal hypoxemia is more marked than diurnal hypoxemia and includes sustained and intermittent components. The potential for cognitive impairments related to nocturnal hypoxemia in this population has not been extensively studied, but improved understanding may provide opportunities for the prevention of long-term effects of EE and CMS.

DIFFUSION MODEL-BASED POSTERIOR DISTRIBUTION PREDICTION FOR KINETIC PARAMETER ESTIMATION IN DYNAMIC PET.

Positron Emission Tomography (PET) is a valuable imaging method for studying molecular-level processes in the body, such as hyperphosphorylated tau (p-tau) protein aggregates, a hallmark of several neurodegenerative diseases including Alzheimer's disease. P-tau density and cerebral perfusion can be quantified from PET data using tracer kinetic modeling techniques. However, noise in PET images leads to uncertainty in the estimated kinetic parameters.

Effects of List-Mode-Based Intraframe Motion Correction in Dynamic Brain PET Imaging.

Motion is unavoidable in dynamic [F]-MK6240 Positron Emission Tomography (PET) imaging, especially in Alzheimer's disease (AD) research requiring long scan duration. To understand how motion correction affects quantitative analysis, we investigated two approaches: II-MC, which corrects for both inter-frame and intra-frame motion, and IO-MC, which only corrects for inter-frame motion. These methods were applied to 83 scans from 34 subjects, and we calculated distribution volume ratios (DVR) using the multilinear reference tissue model with two parameters (MRTM2) in tau-rich brain regions.

Health Status of People Who Are and Are Not Experiencing Homelessness: Opportunities for Improvement.

This study assessed the physical and psychological health parameters of adults experiencing homelessness to inform the development and delivery of health services by comparing with a housed population in the same South Australian city. Adults experiencing homelessness, known to existing support services, were invited to participate in a comprehensive assessment of their physical and mental health using questionnaires and objective assessments. Descriptive analyses using the percentage of participants failing to attain recommended published thresholds and accumulated health deficits for 16 health assessments were compared for the young group of people experiencing homelessness (18-40 years), the middle aged and older people experiencing homelessness (40-75 years), and a housed population of the middle aged and older people (40-75 years).