Publications by authors named "T Laitio"
Background: Abnormal serum potassium levels are commonly found in the intensive care unit (ICU) population. We aimed to determine the prevalence of potassium disorders at ICU admission and its association with functional outcomes in comatose patients resuscitated from cardiac arrest.
Methods: We performed a post hoc analysis of pooled data from four randomised clinical trials involving comatose post-cardiac arrest patients admitted to ICU after return of spontaneous circulation (ROSC).
Article Synopsis
- Inhaled xenon combined with hypothermia was tested on comatose patients who survived out-of-hospital cardiac arrest (OHCA) to see if it could protect gray matter in the brain.
- A study of 110 patients found that those who received inhaled xenon and temperature management showed less reduction in brain gray matter volume, especially in areas like the amygdala and temporal gyrus, compared to those who received only temperature management.
- The results suggest that inhaled xenon can help preserve brain structure in this patient group, highlighting its potential therapeutic benefits.
Article Synopsis
- This study investigates the effects of inhaled xenon on metabolic outcomes in out-of-hospital cardiac arrest survivors receiving targeted temperature management.
- Blood samples showed that increased lactate and decreased branched-chain amino acids (BCAAs) were associated with higher mortality rates at 24 and 72 hours post-arrest.
- The findings suggest that high levels of lactate and alanine, along with low BCAAs and small HDL cholesterol, are linked to negative outcomes, while inhaled xenon did not significantly impact the metabolic profile of patients.
Purpose: To evaluate the potential association between early dysnatremia and 6-month functional outcome after cardiac arrest.
Methods: We pooled data from four randomised clinical trials in post-cardiac-arrest patients admitted to the ICU with coma after stable return of spontaneous circulation (ROSC). Admission natremia was categorised as normal (135-145 mmol/L), low, or high.
Background: This exploratory study aimed to investigate whether dexmedetomidine, propofol, sevoflurane, and S-ketamine affect oxylipins and bile acids, which are functionally diverse molecules with possible connections to cellular bioenergetics, immune modulation, and organ protection.
Methods: In this randomised, open-label, controlled, parallel group, Phase IV clinical drug trial, healthy male subjects (=160) received equipotent doses (EC for verbal command) of dexmedetomidine (1.5 ng ml; =40), propofol (1.